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READING TIME TOPIC 23 [复制链接]

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楼主
发表于 2009-8-31 19:41 |显示全部帖子 |倒序浏览 |打印
Today' s topic is StochasticGeneExpression
% w/ V4 \, m5 T# l  ninaLentiviralPositive-FeedbackLoop:
' T5 J- M! ^0 K# `HIV-1TatFluctuationsDrivePhenotypicDiversity.+ W9 j, w% O/ [5 C
The summary and the paper is in the attachments.
% H" M- i+ \9 o1 you could try to translate the summary2 n5 J/ [4 v/ s6 d( O
2 you could talk about the author or the institute
' \. S" w: T& C( V$ n( }3 you could summarize steps of the experiment or the results
8 g. J+ C; k+ J% q( K* R* d4 you could give your doubts of this paper, v2 U# V7 v. i% S: R3 G; D( ^
5 you could upload your record of the summarize
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) v8 h( d) y# n  e, gIf you want to talk something else, please let me know.
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沙发
发表于 2009-8-31 19:43 |显示全部帖子
This is the whole paper./ T" `8 b; u+ C+ r
StochasticGeneExpression inaLentiviralPositive-FeedbackLoop:
% a" K8 Q( ?' S! d, z& c/ L: a- f+ MHIV-1TatFluctuationsDrivePhenotypicDiversity
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藤椅
发表于 2009-8-31 19:46 |显示全部帖子
David V. Schaffer9 @; {/ P5 w! y
Professor of Chemical Engineering
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1 t( K1 v* r2 y( a: m$ semail: schaffer@berkeley.edu
4 c" O) T3 [0 t- M% `" x7 j+ Soffice: 274 Stanley Hall
3 {2 o) R0 `. O2 _* Yphone: 510.643.5963 ) i) u' C" I6 ~) U! M% C0 r  S. {) C& n
fax: 510.642.4778
0 o6 ^" X" A# z) Q2 O) u! Jlab: 278 Stanley Hall
6 }' D( ^7 M3 }- a9 glab phone: 510.642.4923' {; `+ Z  }+ I! W7 g

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5 b, {0 `7 Q$ Y* u5 mResearch Group% w' u! e$ M7 W# ^3 u7 C* S$ F
Recent Publications. \9 U9 q5 }7 C  H
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Research Interests
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Biomedical Engineering
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We have developed a research program that employs molecular and cellular engineering approaches to attempt to investigate biomedical problems. In particular, our lab is interested in the related areas of gene therapy and stem cell biology, with applications to therapies for diseases of the nervous system.
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Biography
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Assistant Professor. B.S. Stanford University (1993); Ph.D. Massachusetts Institute of Technology (1998). American Chemical Society BIOT Division Young Investigator Award (2006); Van Ness Award Lecturer, Rennselaer Polytechnic Institute (2006); Departmental Citation for Excellence in Teaching (2003); Technology Review Magazine "Top 100 Innovator Under 35" (2002); American Institute of Chemical Engineers (NorCal) Excellence in Teaching Award (2002); Family Faculty Award (2001);National Science Foundation CAREER Award (2001); Office of Naval Research Young Investigator (2001); The Biomedical Engineering Society Rita Shaffer Young Investigator Award (2000); U.C. Berkeley Wills Neuroscience Institute Member (1999); Regents' Junior Faculty Award (1999).

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板凳
发表于 2009-9-1 19:46 |显示全部帖子
干细胞之家微信公众号
Adam P. Arkin, Ph.D.  ( b( d+ A; h- d, p# |) S; M/ E
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1 N+ R7 H& |8 m: n: y' qDr. Arkin is Associate Professor of Bioengineering at the University of California, Berkeley; Adjunct Professor of Biochemistry and Biophysics at the University of California, San Francisco; Faculty Scientist in the Physical Biosciences Division at Lawrence Berkeley National Laboratory; and Director of the Virtual Institute for Microbial Stress and Survival. He received his Ph.D. degree in physical chemistry from the Massachusetts Institute of Technology. He then pursued postdoctoral studies at Stanford University in chemistry with John Ross and in developmental biology with Harley McAdams and Lucy Shapiro. Dr. Arkin was recently elected a fellow of the American Academy of Microbiology.
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RESEARCH ABSTRACT SUMMARY:4 m6 u2 U* y* R0 F/ k7 V$ [

3 O$ n' i/ u  ]: j- j6 M2 z, c" IAdam Arkin is interested in the evolutionary design principles of cellular regulatory networks and how these principles aid in the prediction, control, and design of cellular behaviors. His lab develops physical theory and computational tools for understanding cellular processes such as gene expression, signal transduction cascades, and cytomechanics. The lab also analyzes genomic data relevant to the dynamics of regulatory networks in a number of viral, bacterial, and eukaryotic systems, and performs experiments to test the theories.

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报纸
发表于 2009-9-3 21:02 |显示全部帖子
International Applicants: n, h! ^3 W! n
Graduates of recognized academic institutions outside the United States should hold a degree equivalent to a U.S. bachelor's degree. Equivalency is determined by International evaluators in the Graduate Admissions Office.0 Y9 K$ z. q7 k+ m' W- {* R' j
Required Records: Submit official transcripts or academic records for all university-level studies you have completed, at U.S. institutions and abroad. If your academic records do not include official evidence of the award of your degree, you must also submit additional documents that verify its award. For information about the documents required for an initial review of your application, contact the department or program to which you are applying.
3 t7 b! j+ r* a* YAcademic records should be issued in their original languages accompanied by English translations (usually prepared by your university or governmental agency, unless the institution issues original documents in English). In general, records or transcripts must be issued by the school and include the school’s stamp or embossed seal and the signature of the authorizing official. For more detailed information on acceptable documents, please contact Graduate Admissions. : j4 E4 C% {7 j2 r' d' P3 N8 f, U% _
In English translations, degree names and grades should be transliterated, not converted into English words or the U.S. grades of A-F. If you must obtain a translation while in the United States, versions prepared by certified members of the American Translators Association are acceptable.3 ?5 \9 p, R- y1 ]; e; d& h$ k8 C6 R
If you have attended a university in the U.S., please ask the registrar there to send your department an official transcript.0 t) M4 x0 m- g( j; f0 A2 J
The Graduate Division may verify the authenticity of academic letters of recommendation with the school or recommender.
- }3 X/ U! I1 t1 _3 \; }" L- `Evidence of English Language Proficiency8 ~; m; }! O# D% ^: ~
All applicants from countries in which the official language is not English are required to submit official evidence of English language proficiency. This requirement applies to applicants from Bangladesh, Nepal, India, Pakistan, Latin America, the Middle East,  Israel, the People’s Republic of China, Taiwan, Japan, Korea, Southeast Asia, most European countries, and non-English-speaking countries in Africa.
3 G! c% k0 n5 K7 g9 T8 QIf you have completed at least one year of full-time academic course work with grades of B or better in residence at a U.S. university, you do not need to take a standardized test. Instead, you must submit an official transcript from the U.S. university. 4 m4 f: `2 L7 L  O. U1 j& k
There are two standardized tests you may take: the Test of English as a Foreign Language (TOEFL), and the International English Language Testing System (IELTS).   n0 B6 t5 i7 P# j! u" ^
Test of English as a Foreign Language (TOEFL) 8 r! x. K+ R5 }* u# j
TOEFL is administered by the Educational Testing Service. You can obtain detailed information from the TOEFL website, or contact TOEFL Services, Educational Testing Service, P.O. Box 6151, Princeton, NJ 08541-6151, (609) 771-7100. Copies of the TOEFL Bulletin are also available at U.S. educational commissions and foundations, binational centers, and private organizations such as the Institute of International Education (IIE).  h  V0 ^' D2 E4 v
To schedule an appointment for the computer-based test in the United States or Canada, call 800-GO-TOEFL.# _. t& }  ]1 ~* Z* H
We will only accept TOEFL tests administered by the Educational Testing Service and sent to us directly by the TOEFL office. Tests taken before June 2008 will not be accepted even if your score was reported to Berkeley. The institution code for Berkeley is 4833. You may submit a photocopy of the Examinee’s Score Report for review purposes only, but this is not a substitute for an official score report.
% X9 g* a1 l6 ?2 o" j, nFor purposes of admission, your most recent score must be at least 570 for the paper-and-pencil test, at least 230 for the computer-based test, or at least 68 for the Internet-based test (iBT). Please contact individual academic departments for more information, as they may choose to require a higher score.
8 }% B% o4 D+ X9 z+ qThe iBT emphasizes integrated skills so that its format and scoring are different from either the CBT or the paper version of the TOEFL. Please plan to take the TOEFL as soon as possible, regardless of the test’s format, to avoid delays in the review of your application.
1 R/ x) c& e4 i5 n1 @  @$ P. hInternational English Language Testing System (IELTS)
$ D) r9 c, n' H# o2 o/ I5 o; }7 wAs an exception, you can submit scores from the Academic Modules of the International English Language Testing System (IELTS), which is jointly managed by the British Council, IDP:IELTS Australia, and the University of Cambridge ESOL Examinations.
9 i# A  Z+ U/ r- g" }! F4 d) eYou are responsible for providing us with an official Test Report Form (TRF) of your IELTS. Remember to order the TRF when you register to take the test.
( H. A$ u: I8 y6 {8 J, fTests taken before June 2008 will not be accepted by Graduate Admissions. Your most recent overall Band score must be at least 7 on a 9-point scale.
1 Y! _& M; W6 L% c, s. e4 d; }& f4 W+ wTo register for the IELTS, consult the IELTS website to locate the office of the test center where you plan to take the test.- O) u9 \$ K& m
Graduate Record Examination (GRE)( k$ D1 d# j% p
Most departments, schools, and groups require applicants to take a standardized test such as the General Test of the GRE, a Subject Test of the GRE, the GMAT, MCAT, OAT, or LSAT. Consult the department to which you are applying for its requirements. To send an official score to Berkeley, list the institution code assigned by the Educational Testing Service (ETS) for Berkeley, 4833. In addition, list the ETS code for the department to which you are applying. If more than one department code might be appropriate, check the department’s instructions on which code to use.
1 ?% u/ Z3 l8 ^- E/ nDates and information for computer-based testing (CBT) may be obtained by contacting the Educational Testing Service (ETS) at the address below, by calling 1-800-GRE-CALL, or by consulting the GRE website.
( f! j/ q9 s$ E8 `: x5 L8 b! D+ |Applications for the GRE can be obtained from the Educational Testing Service, Box 6000, Princeton, NJ 08541-6000, (609) 771-7670, or the website.
3 _! n# G+ g- @/ N( uDomestic candidates from families with extremely low incomes may qualify for a waiver of GRE test fees. Consult your undergraduate financial aid office to determine whether your institution participates in the GRE Fee Waiver Program and whether you qualify. Fee waivers are not available directly from the Educational Testing Service or from the Graduate Division.
$ B7 D: M7 q. A9 k, f, h3 rLetters of Recommendation
  W+ H. C& ?8 d6 |! E1 C# G' V, XApplicants who use the online application should check to see if their program accepts online recommendations. Applicants using the paper application should follow the instructions below.3 ^' @+ ^1 y3 i' v9 w+ Q' T+ a
At least three letters of recommendation are required. Please print your name and the department to which you are applying clearly at the top of the forms (Letter of Recommendation). Use departmental recommendation forms instead of "the graduate application Letter of Recommendation form" if instructed to do so by the department.& t; N' A' Z, H: b  u
You are responsible for forwarding these forms to your recommenders. All letters of recommendation should be submitted directly to the department to which you are applying. Some departments have early deadlines for fellowship applicants. Be sure to inform your recommenders of the department’s deadline.
) s, ^: S( _# J# e9 sYour recommenders are asked to give their personal impressions of your intellectual ability, your aptitude in research or professional skills, your character, and the quality of your previous work and potential for future productive scholarship.
9 }* R' W3 c9 H, a* ZApplicants may waive the right to inspect their letters of recommendation on a voluntary basis. To waive access to your letters, complete the waiver section of the Letter of Recommendation. We may verify the authenticity of the letters of recommendation.
8 {' V. E; i, s# WCourse Work Only Status
+ Y2 i, X2 _8 \; xIf you want to undertake graduate study without working for a higher degree, you may apply for course-work-only status. You must, however, meet the same admission requirements as degree candidates, have a definite scholarly or professional purpose in applying, and be admitted to a regularly established major field of study. There is no limited or unclassified status available to graduate students. Course work only students do not qualify for fellowship consideration or for academic appointment as a Graduate Student Instructor and can be accommodated only if a department is willing to include them in its enrollment target. Not all departments accept course work only students. Please check with your academic department before starting an application. There is a maximum of two semesters of study. Admission to course work only status precludes all future admission to any degree program at UC Berkeley.
* C3 h# d& P9 m2 f9 O4 T* b" cDuplication of Doctoral Degree
9 f2 ?: `: R: @! h1 X/ X) F$ PStudents who already hold a doctoral level degree are not admitted and duplication of degree or admission to a lesser degree is not permitted. However, in extraordinary circumstances, the faculty of the department may request an exception from the Dean of the Graduate Division. The department must demonstrate that the second degree field of study and program are distinctly different from that of the original degree, and that there is a professional or scholarly purpose that requires this second degree.
. A# H# g. s0 }: n& @, s- r: ?University Extension, Concurrent Enrollment
$ D# e, Z$ ^1 n9 }Concurrent courses are those taken through University Extension under the instruction of a regular member of the Berkeley faculty. Concurrent enrollment cannot replace normal registration by Berkeley graduate students, nor can it be used to accumulate credit toward a degree from Berkeley. Berkeley Division regulation A208 allows UC Berkeley Extension courses carrying the “XB” designation on University Extension transcripts to be accepted for unit, requirement and grade-point credit on the Berkeley campus under specific conditions (see the Academic Senate website). Exceptions will be considered only upon the recommendation of a Graduate Adviser to the Dean of the Graduate Division and only when it is evident that a student was in graduate standing at an institution other than Berkeley when he or she undertook the course work.8 G; [( L$ X) h" Z+ v3 D; m
Transfer of Credit from Other Institutions
/ M1 [) _5 l+ J4 O. L2 eYou cannot transfer credit from other institutions if you are seeking a Ph.D. degree. Up to six quarter units or four semester units of credit for work you have taken elsewhere can be credited toward the master’s degree if (a) the work was taken in graduate status at an accredited institution, (b) it did not form part of a program for a degree previously awarded at Berkeley or elsewhere, and (c) the grade received was at least a “B” and the student’s overall GPA at both institutions was at least 3.3. Acceptance is subject to the approval of the Graduate Division upon recommendation of the department concerned. Transfer of credit will not reduce your academic residence requirements or the required minimum of 200-series courses in the major field.  p) x, _, @: J; m
Summer Sessions5 P9 \9 a( ^9 j. e0 g1 H" g
To apply for admission to the Summer Sessions, visit the Summer Sessions website. Registration and fee payment may be completed online. Course work completed in a Summer Session immediately preceding the initial fall enrollment may apply toward a graduate program.

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地板
发表于 2009-9-3 21:10 |显示全部帖子
GPA害死人啊,UCberkeley竟然比Harvard  要的积点还高。: m0 h: |7 `/ J. a

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7
发表于 2009-9-3 21:11 |显示全部帖子
HIV-1Tat反式激活元件是完成病毒生活史重要因素同时暗示了决定前病毒潜在因素。我们就HIV-1模型载体进行了大量实验和计算上的研究,结果表明tat的随机波动影响了病毒潜在因素的判断。低GFP/Tat表达导致来自同一前病毒克隆群体向两个表形分化同时表现出非常高和接近零GFP表达。虽然表形分化是不同基因型融合模式,既不是这些模式也不是其他额外的细胞因子所解释的表形分化。随机计算模型成功的计算出了表形分化,并随后用实验证明了正确的预测一个TAT突变的效率,因此Tat随机显现出的大量的表形分化,阐明了哺乳动物基因表达中随机波动的重要性。
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