神经干细胞移植的临床研究进展

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朱剑虹1,2,3*，王　璞1,2,3，沈亦雯1,2,3，陈露萍1,2,3
  y. g( v/ [( G: y# z4 t' s（1复旦大学附属华山医院神经外科，医学神经生物学国家重点实验室，上海 200040；2复旦大学脑科学研究院，上海 200032；3复旦大学上海医学院，上海 200032）
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& A4 q3 l: Z. d6 e0 }) g摘　要：神经系统损伤会导致脑内神经干细胞(neural stem cells, NSCs)的扩增以实现自我修复功能，而通过外源细胞移植的方式来加速这一进程，可能是一种更有效的治疗手段。当前，神经干细胞临床研究所面临的主要问题是如何评价细胞在移植后的行为和功能。该文综述了近几年使用神经干细胞移植治疗几种主要神经系统疾病的临床研究成果，并着重关注了干细胞移植后的示踪研究。
. ?: L9 I! X8 H- S" T5 f6 P关键词：干细胞；神经干细胞；移植；干细胞示踪
7 P: n6 b' ]/ s中图分类号：Q813　　文献标识码：A' j5 E3 O1 \5 h0 m5 T' ]& @

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) N* f0 H- z. o/ X' cAdvances of transplantation of neural stem cells ) I: c6 z4 b' L: E  {: S0 N
ZHU Jian-hong1,2,3*, WANG Pu1,2,3, SHEN Yi-wen1,2,3, CHEN Lu-ping1,2,3 # a% _0 [! R) j+ a+ H' b) p. _) c* |
(1 State Key Laborafory of Medical Neurobiology, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; 2 Institutes of Brain Science, Fudan University, Shanghai 200032;  
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' e9 U4 x) }5 f* N% C4 kAbstract: Injuries to nervous system induce neural stem/progenitor cell proliferation in adult brain which might be an endogenous attempt to self-repair. Transplantation of stem cells into the injured brain may be a future therapeutic option to replace the lost neurons. A major challenge to the development of this strategy is to evaluate the fate of exogenous cells after transplantation. This review will focus on the progress of neural stem cell -based cell therapies for neurological diseases and pay great attention to the tracking study of implanted neural stem cells.
$ i% q) _, I  ?9 ~& U. m6 ^Key words: stem cell; neural stem cell; transplantation; clinical trail; stem cell tracking

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