肿瘤干细胞研究进展-潘秋辉

sunca

5 B0 E8 D$ `, B+ D
% R' ?0 R# n: Y& d: ]4 U7 `
潘秋辉1，宋尔卫2* 8 l# f  ^- N+ H  K! H) @6 T# x1 Z6 D
（1中山大学附属第二医院医学研究中心，广州510120；2中山大学附属第二医院乳腺外科，广州510120） " W6 T; F+ y! j2 q
" d& H$ j7 Q8 M" }: o. s& X7 @
摘　要：在过去的十年中，肿瘤干细胞(cancer stem cell/tumor-initiating cell, CSC/TIC)虽然受到广泛重视，但也是争论的焦点。如何正确认识CSCs假说，以及CSCs的生物学特点和CSCs的治疗应用这些问题都存在巨大的争议。该文对CSCs的起源、分离鉴定的方法，以及信号通路、微环境等对CSCs的调控关系，肿瘤的最佳治疗途径等问题进行综述。
1 d' I( d8 b9 C关键词：干细胞；肿瘤干细胞；肿瘤治疗；分选鉴定
0 P6 j; q% |, J中图分类号：R730.231　　文献标识码：A　　
3 L+ Z- @- K9 {+ `7 V' V! @' H8 V
/ x2 o. `+ `+ c9 R3 b ) }3 V* |2 O) {" J8 i3 n( X
  
  e  B( C$ _5 i) S! V6 C2 q
3 Z' P; t# R: O; e; u$ l  + f* }; m2 e6 b/ _( V
Research progress of cancer stem cells " a6 B$ B6 ]- p* L& u' t- z
PAN Qiu-hui1, SONG Er-wei2*
3 c# q* N' ]. G(1 Medical Research Center, second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China2 Department of Breast Surgery, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China);  
4 J5 S/ y+ H8 N6 u8 f ! y. Z) ?- o( k# P$ _
0 @  ]! S( {/ a; j" ^$ k$ Z
Abstract: The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past decade but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following text, we discuss the origin, the identification, regulatory pathway, microenviroment and the new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.2 r5 \! H: ^1 h! q: B9 v" F6 T
Key words: stem cell; cancer stem cell; cancer therapy; identification of sorfing8 D) z: I5 V' I& j& E
: V+ o3 N1 p3 l4 _. i
原文在7楼 感谢cortex 提供