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本帖最后由 细胞海洋 于 2016-1-22 12:10 编辑 + ~3 o. U" P8 Q6 a# m+ A
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Epigenetics
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: t, n7 D1 x! a' LEdited By C. David Allis, The Rockefeller University, New York; - R; K- E# \/ g9 N; b V. c& p! e
Thomas Jenuwein, Research Institute of Molecular Pathology, Vienna;
( f: `' n* b! |7 c3 M3 ^Danny Reinberg, Howard Hughes Medical Institute/University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School;
$ m: s1 u( o' P5 Z0 u4 v. {0 RMarie-Laure Caparros, Associate Editor
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Description
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The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.8 Y ?2 Q% E9 I& W$ i
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Contents0 u! _2 i& I9 a2 h+ D: r, y
1. Epigenetics: From Phenomenon to Field
7 o, x1 b+ x6 F. D6 q8 aD.E. Gottschling
% Q7 v4 W/ }8 N$ F, \; \2. A Brief History of Epigenetics
3 J3 ? n5 _4 F' IG. Felsenfeld% X0 X- ?' G1 N4 s
3. Overview and Concepts6 P5 v4 b8 K% J& ]! Y$ T G+ B
C.D. Allis, T. Jenuwein, and D. Reinberg
) H- s& `+ I7 W& b9 R( \& n. `4. Epigenetics in Saccharomyces cerevisiae
% w+ h; L4 y1 l8 W& {- ^9 l3 TM. Grunstein and S. Gasser7 `8 d6 \3 y/ a- I" _- G4 `
5. Position Effect Variegation, Heterochro-matin Formation, and Gene Silencing in Drosophila
P8 k0 c7 x$ G hS.C.R. Elgin and G. Reuter
; F! L8 Z3 D+ V9 D6 H+ X; C( v% a* g6. Fungal Models for Epigenetic Research: Schizosaccharomyces pombe and Neurospora crassa ?6 I0 z' l* v i) J
R.C. Allshire and E.U. Selker
/ a4 Y- Y$ D8 u @7. Epigenetics of Ciliates
9 @2 a+ h' v1 P, } G0 b, k3 W: WE. Meyer and D.L. Chalker
% c' ^; W9 x- N/ ~% A! z! W8. RNAi and Heterochromatin Assembly3 p9 T( d8 d5 t: z9 r+ D+ h p
R. Martienssen and D. Moazed7 b, B l3 b! d4 R$ A
9. Epigenetic Regulation in Plants
4 d, _, {1 y: }+ ]+ J `M. Matzke and O. Mittelsten Scheid
. j* Y7 R6 W+ ~3 u* I0 h2 Z! n10. Chromatin Modifications and Their Mechanism of Action
) q! @4 W9 p2 i1 b+ A) GT. Kouzarides and S.L. Berger
" C! x% Z8 P6 [# J4 m11. Transcriptional Silencing by Polycomb Group Proteins
$ H f' U+ R# W! X2 oU. Grossniklaus and R. Paro
+ S6 A$ Z$ U4 G' `8 M5 l3 m7 @12. Transcriptional Regulation by Trithorax Group Proteins
" i# m# d5 J; g OR.E. Kingston and J.W. Tamkun
% Z5 h+ v; ^! f# U- g13. Histone Variants and Epigenetics( j) P' T: s4 t4 r, Z7 x
S. Henikoff and M.M. Smith
+ ]! E) i* O1 @$ d' ?14. Epigenetic Regulation of Chromosome Inheritance% A" g" C6 I K
G.H. Karpen and R.S. Hawley
2 ?! v$ X1 c7 |# ~8 T- W0 P9 T3 a15. Epigenetic Regulation of the X Chromosomes in C. elegans
" |, N1 [" Z/ I4 @/ zS. Strome and W.G. Kelly8 j& ^" w% y: b+ b) v
16. Dosage Compensation in Drosophila
* ~, y+ m5 u. T6 @" H+ zJ.C. Lucchesi and M.I. Kuroda
B1 v# {) e, N6 \17. Dosage Compensation in Mammals( d/ M! S& P+ ]* Q; x% K
N. Brockdorff and B.M. Turner
6 a% U1 i8 `. b5 L/ u4 Z! Y18. DNA Methylation in Mammals* b. W; x; \$ A8 W. L
E. Li and A. Bird* m% ^& h, l( p' _' U8 i E: c4 z
19. Genomic Imprinting in Mammals+ Q$ F' I5 N- g4 T) U8 B
D.P. Barlow and M.S. Bartolomei
2 m" T' _$ O3 W; Q9 n+ k. a5 c20. Germ Line and Pluripotent Stem Cells: R4 W' |: Q' l( e7 k
M.A. Surani and W. Reik( i7 W, Y/ x$ X* t2 G X- ]
21. Epigenetic Control of Lymphopoiesis% [: f. V3 o, a) m) Y- C* b# [. u% l
M. Busslinger and A. Tarakhovsky
9 w7 X8 O! V' C5 k# `& E4 F# g22. Nuclear Transplantation and the Reprogramming of the Genome/ G1 Y0 [/ U6 ~! |# |7 Q0 l* j" G
R. Jaenisch and J. Gurdon% h% ~1 N2 C) j
23. Epigenetics and Human Disease
& l6 e6 S' I4 z+ B2 r) rH.Y. Zoghbi and A.L. Beaudet
5 ^6 d+ n1 j! Q; P+ p- |; b24. Epigenetic Determinants of Cancer! r5 [1 Y" Q2 c/ o: z0 r; V
S.B. Baylin and P.A. Jones: a9 @7 U, ?# w2 F* r1 i' G
Appendices
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