PDF电子书《microRNAs From Basic Science to Disease Biology》

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8 w6 s5 K, _+ o' GmicroRNAs From Basic Science to Disease Biology  P% u; e- m6 r; Q  h  o# }0 `
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MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their discovery has revolutionised both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development.
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0 s' }# I1 F+ l. bForeword; Foreword; Introduction Part I. Discovery of MicroRNAs in Various Organisms: 1. The microRNAs of C. elegans; 2. Non-coding RNAs - development of man-made vector-based intronic microRNAs; 3. Seeing is believing: strategies for studying microRNA expression; 4. MicroRNAs in limb development; 5. Identification of miRNAs in plant oryza sativa; Part II. MicroRNA Functions and RNAi-mediated pathways: 6. Inhibition of translation initiation by a microRNA; 7. In situ analysis of microRNA expression during vertebrate development; 8. MicroRNA function in the nervous system; 9. Micro RNA expression that controls the amount of branched chain α-ketoacid dehydrogenase in mitochondria of human cells; 10. MicroRNAs and the regulation of leaf shape; Part III. Computational Biology of microRNAs: 11. miRBase: a database of microRNA sequences, targets and nomenclature; 12. Computational prediction of microRNA targets in vertebrates, fruitflies and nematodes; 13. Computational approaches to elucidate miRNA biology; 14. The RNA hybrid approach to microRNA target prediction; 15. Machine learning predicts microRNA target sites; 16. Models of microRNA-target coordination; Part IV. Detection and Quantitation of MicroRNAs: 17. Detection and analysis of microRNAs using LNA (locked nucleic acid)-modified probes; 18. Detection and quantitation of microRNAs using the RNA Invader® assay; 19. A single molecule method to quantify miRNA gene expression; 20. Real-time quantification of MicroRNAs by TaqMan® assays; 21. Real-time quantification of miRNAs and mRNAs employing universal reverse transcription; Part V. MicroRNAs in Disease Biology: 22. Dysregulation of microRNAs in human malignancy; 23. High throughput microRNAs profiling in cancers; 24. Roles of microRNAs in cancer and development; 25. miR-122 in mammalian liver; 26. MiRNAs in glioblastoma; 27. Role of microRNA pathway in Fragile X mental retardation; 28. Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia; 29. miRNAs in TPA-induced differentiation of HL-60 cells; 30. MiRNAs in skeletal muscle differentiation; 31. Identification and potential function of viral microRNAs; 32. Lost in translation: regulation of HIV-1 by microRNAs and a key enzyme of RNA-directed RNA polymerase; Part VI. MicroRNAs in Stem Cell Development: 33. MicroRNAs in the stem cells of the mouse Blastocyst; 34. The role of miRNA in hematopoiesis; 35. MicroRNAs in embryonic stem cell differentiation and prediction of their targets; 36. Generation of single cell microRNA expression profile.
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Reviews
- o5 N" r1 [- L) ~! D4 p/ ^5 ?'…comprehensive and detailed…compiled logically…informative and easy to read.' Microbiology Today
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'Overall, a useful reference guide for those interested in miRNA …' Immunology News8 V* s- s: S, B7 I4 |# e2 I
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Contributors6 }& J2 E( c: Z( ~9 P/ N- b3 t2 q. k: {
Sidney Altman, Victor R. Ambros, Krishnarao Appasani, Ines Alvarez-Garcia, Eric A. Miska, Shao-Yao Ying, Joseph D. Miller, Shi-Lung Lin, Joshua W. Hagen, Eric C. Lai, Danielle M. Maatouk, Jason R. Rock, Brian D. Harfe, Hui Zhou, Yue-Qin Chen, Yu-Chun Luo, Jia-Fu Wang, Liang-Hu Qu, David T. Humphreys, Belinda J. Westman, David I. K. Martin, Thomas Preiss, Diana K. Darnell, Stacey Stanislaw, Simran Kaur, Tatiana A. Yatskievych, Sean Davey, Jay H. Konieczka, Parker B. Antin, Gerhard Schratt, Michael Greenberg, Dean J. Danner, John Barnes, Benjamin Mersey, Ramiro E. Rodriguez, Carla Schommer, Javier Palatnik, Anton J. Enright, Sam-Griffith-Jones, Dominic Grün, Nikolaus Rajewsky, Praveen Sethupathy, Molly Megraw, Artemis G. Hatzigeorgiou, Marc Rehmsmeier, Pål Sætrom, Ola Snøve Jr., Neil R. Smalheiser, Vetle I. Torvik, Sakari Kauppinen, Hatim T. Allawi, Victor I. Lyamichev, Sonal Patel, Joanne Garver, Michael Gallo, Maria Hackett, Stephen McLaughlin, Mark Nadel, John Harris, Duncan Whitney, Lori A. Neely, Yu Liang, Linda Wong, Ruoying Tan, Caifu Chen, Gregory J. Hurteau, Simon D. Spivack, Graham J. Brock, Kathryn A. O'Donnell, Joshua T. Mendell, Muller Fabbri, Ramiro Garzon, Amelia Cimmino, George Adrian, Carlo Maria Croce, Andrea Ventura, Madhu S. Kumar, Tyler Jacks, Jinhong Chang, John M. Taylor, Silvia Anna Ciafrè, Keith Szulwach, Peng Jin, Takashi Sonoki, Norio Asou, Tomoko Kozu, Irina Naguibneva, Anna Polesskaya, Annick Harel-Bellan, Finn Grey, Alec J. Hirsch, Jay A. Nelson, Yoichi Robertus Fujii, Hristo B. Houbaviy, Michaela Scherr, Matthias Eder, Yvonne Tay, Andrew M. Thomson, Bing Lim, Fuchou Tang, Kaiqin Lao, M. Azim Surani7 ]5 ~. }* h& }: a* E
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