PDF电子书《MicroRNA Interference Technologies》2009

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MicroRNA Interference Technologies 9 ~0 H8 F% w! w& r7 P

" q0 q& ^. Y; c3 ]Abstract: H' c* O2 `% N- u3 P/ J% }
The miRNA pathways are highly responsive to interventions of any kind, being excellent candidates for pharmacological manipulation. Mature miR-NAs belong to a category of non-coding small RNAs. They are very different from traditional messenger, ribosomal, or transfer RNA in their biogenesis, structures and functions. The technologies used to study traditional RNAs in basic research and to manipulate traditional RNAs for therapeutic purpose, for the most part, would be ineffective for miRNAs. New technologies for studying miRNA are therefore in need and this demand is being met by the scientific community at a breakneck pace. In the past few years, from the discovery of miRNAs in humans, numerous new technologies have been developed to clone, profile, visualize, quantify and manipulate miRNAs. This book centers on the technologies for manipulating miRNAs. $ |5 k! a' u  w* ~: Q" ^
An overview of the concept of microRNA interference (miRNAi) and another three related concepts and a brief introduction to the miRNAi technologies is given in this chapter, to help readers better understand the technologies. The applications of these technologies to miRNA research and the potential for gene therapy of related diseases are also summarized and speculated. Detailed descriptions of these technologies are provided in the following chapters.

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