求助1篇science文献（已给出链接），多谢了！！！

sunyucheng

http://www.sciencemag.org/cgi/reprint/321/5891/964.pdf' P6 _8 ~7 M! g9 b* Z

# X$ a. L2 t6 T' dSuppression of the MicroRNA Pathway by Bacterial Effector Proteins
+ w7 E( h( i- M) _5 rLionel Navarro,1 Florence Jay,1 Kinya Nomura,2 Sheng Yang He,2 Olivier Voinnet1* ! `" R5 a% o9 ^9 _& ]6 ]

5 S5 K4 ?( E5 c3 r4 z1 l" aPlants and animals sense pathogen-associated molecular patterns (PAMPs) and in turn differentially regulate a subset of microRNAs (miRNAs). However, the extent to which the miRNA pathway contributes to innate immunity remains unknown. Here, we show that miRNA-deficient mutants of Arabidopsis partly restore growth of a type III secretion-defective mutant of Pseudomonas syringae. These mutants also sustained growth of nonpathogenic Pseudomonas fluorescens and Escherichia coli strains, implicating miRNAs as key components of plant basal defense. Accordingly, we have identified P. syringae effectors that suppress transcriptional activation of some PAMP-responsive miRNAs or miRNA biogenesis, stability, or activity. These results provide evidence that, like viruses, bacteria have evolved to suppress RNA silencing to cause disease.

bardey

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回复 [url=http://www.stemcell8.cn/redirect.php?1 u  r* S1 P; p7 D
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sunyucheng

多谢！！！

sin_007

这篇文章很有意思啊