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sunyucheng

Science. 2005 Apr 22;308(5721):557-60.1 f" X6 f" y: V

; j* Y9 ?2 g. G* w0 ~* U6 YA cellular microRNA mediates antiviral defense in human cells.
9 L+ O% x1 K. c2 W; s  ZLecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, Saïb A, Voinnet O.
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CNRS Unité Propre de Recherche (UPR) 2357, Institut de Biologie Moléculaire des Plantes, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France. charles.lecellier@infobiogen.fr$ Q  O0 a' x/ X5 K0 m" Q7 y( D
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Comment in:
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+ D& _. A$ c  Q/ z3 L/ K. eScience. 2005 Apr 22;308(5721):480-1. , D" R# E' p; {; C3 u
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In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions.

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sunyucheng

多谢！！！