cell文献求助

junshen

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
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3 @! @+ T* e8 Qhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWK-4YM3SYF-7&_user=2001593&_coverDate=03%2F16%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050602&_version=1&_urlVersion=0&_userid=2001593&md5=8156e9318676ae072ff8946645ebc174

待鹤

Too new for us to access it. Only abstract here.
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Cancer Cell DOI 10.1016/j.ccr.2009.12.0431 A" P# |- K: a3 [/ X. V. C
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence$ W, q3 H) D1 d! c
Maurice Reimann, Soyoung Lee, Christoph Loddenkemper, Jan R. D?rr, Vedrana Tabor, Peter Aichele, Harald Stein, Bernd D?rken, Thomas Jenuwein, Clemens A. Schmitt
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: R3 h1 a* c, i& AActivated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked DNA damage response (DDR). In contrast, Myc activation—although producing a DDR as well—is known to primarily elicit an apoptotic countermeasure. Using the Eμ-myc transgenic mouse lymphoma model, we show here in vivo that apoptotic lymphoma cells activate macrophages to secrete transforming growth factor β (TGF-β) as a critical non-cell-autonomous inducer of cellular senescence. Accordingly, neutralization of TGF-β action, like genetic inactivation of the senescence-related histone methyltransferase Suv39h1, significantly accelerates Myc-driven tumor development via cancellation of cellular senescence. These findings, recapitulated in human aggressive B cell lymphomas, demonstrate that tumor-prompted stroma-derived signals may limit tumorigenesis by feedback senescence induction

aspen

enjoy!

victorhan

h恩感谢，已经下了

58062782

谢谢