|
- 积分
- 5
- 威望
- 5
- 包包
- 6
|
CANCER STEM CELLS: BACK TO DARWIN?
7 h' B4 o8 s& i# x: C7 ]. {' J6 _: a
Semin Cancer Biol. 2010 Mar 29;
6 ~1 o3 ~% d' r7 h; A
( ^ z; m8 Z- K, E- O$ x& k, d$ H" sAuthors: Greaves M
+ o* w' ~4 i" P2 m1 j* o3 P; y* H. ?0 R) W
Current models of cancer propagating or 'stem' cells pay scant attention to the evolutionary dynamics of cancer or to the underlying genetic, mutational drivers. Recent genetic studies on acute lymphoblastic leukaemia at the single cell level reveal a complex non-linear, branching clonal architecture-with sub-clones having distinctive genetic signatures. Most cancers appropriately interrogated are found to have intra-clonal genetic heterogeneity indicative of divergent clonal evolution. These data further suggest that clonal architecture might be driven by genetic heterogeneity of propagating or 'stem' cells. When assayed for leukaemic regeneration in NOD/SCID/gamma mice, genetically diverse 'stem' cells read-out, broadly reflecting the clonal architecture. This has suggested a 'back to Darwin' model for cancer propagation. In this, cells with self-renewal potency or 'stem-ness' provide genetically diverse units of evolutionary selection in cancer progression. The model has significant implications for targeted cancer therapy. |
-
总评分: 威望 + 5
包包 + 5
查看全部评分
|
发表于 2010-4-8 21:05
