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- 积分
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- 威望
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- 包包
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干细胞研究进展和未来研究的方向
$ `4 N; C* s+ X' RStem Cells--Scientific progress and future research directions
% A& B# K4 O' T+ }Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . i7 O) h' ?/ j0 {- z+ z
Executive Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . ES-1
/ P0 ~% D& I6 q- d5 iChapter 1: The Stem Cell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
. L' `) E) _& P0 }$ rChapter 2: The Embryonic Stem Cell . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . 5$ g% H% C; w4 O
Chapter 3: The Human Embryonic Stem Cell+ j, c6 Z5 x0 b3 |; I1 ^
and The Human Embryonic Germ Cell . . . . . . . . . . . . . . . . . . . . . . . . . 11
/ F2 W ^' i: W) a" \Chapter 4: The Adult Stem Cell . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . 23/ u4 z; J4 w1 w7 @% E9 j
Chapter 5: Hematopoietic Stem Cells . . . . . . . . . . . . . . . . . . . . . . . 43( a5 K5 I* M N/ z3 ]
Chapter 6: Autoimmune Diseases and the Promise$ ~+ a$ _) x. F) Y. c
of Stem Cell-Based Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
# C# z7 Q2 y) L3 r2 cChapter 7: Stem Cells and Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
) g& s: k. D* W4 v+ v% OChapter 8: Rebuilding the Nervous System with Stem Cells . . . . . . .. . . . . . 77
* `3 ]; r- X \0 r3 pChapter 9: Can Stem Cells Repair a Damaged Heart? . . . . . . . . . . . . .. . . . . . 87# @! g: V8 R8 y, N
Chapter 10: Assessing Human Stem Cell Safety . . . . . . . . . . . . . . . . . . . . . 93
1 V6 H+ j7 ^7 ?4 @6 Y5 }2 Z8 P! ]Chapter 11: Use of Genetically Modified Stem Cells in
3 u( k2 D* G) m% d8 s1 H* }Experimental Gene Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
4 R' Y; ?" j0 N% tAppendix A: Early Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A-15 E b Z8 L; g) x9 l
Appendix B: Mouse Embryonic Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . B-1
! ^/ ^3 H I5 NAppendix C: Human Embryonic Stem Cells and Embryonic Germ Cells . . . . . . . C-1
8 F4 p; Y5 E% i6 ]Appendix D: Stem Cell Tables3 R: C0 g1 |& L& G% \+ g! ~
i. Published Reports on Isolation and Differentiation of Mouse
5 @( }" p$ _* r3 D6 HStem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D-2/ C" r; E Y) t! [. o9 _
ii. Published Reports on Isolation and Differentiation of Human( H6 e4 h- s, @" C; s0 v" B
Fetal Tissue Germ Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D-130 I7 V5 C m' P' t( Y& Y) D6 Q
iii. Published Reports on Isolation and Differentiation of Human
; ^; q" J- p, M2 g) ^& R7 kEmbryonic Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D-14
- }3 c3 K, {0 X* |. Z; }, O0 Ziv. Published Reports on Isolation and Differentiation of Human
9 {- x$ h5 S) H+ o1 p8 @Embryonic Carcinoma Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . D-16
: y5 D5 [3 B4 |2 ~: s9 i$ av. Published Reports on Isolation and Differentiation of Human6 @4 R# M( N: R, U9 y
Adult Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D-18 M7 E3 U# l! o" g
vi. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D-222 S7 h. O% N; y- B
Appendix E: Stem Cell Markers7 f; ^& m) ?% }" v( @
i. Markers: How Do Researchers Use Them to Identify Stem Cells? . . . . . E-1
a* y4 L% C1 W2 F- oii. Commonly Used Markers to Identify Stem Cells and3 Q7 A6 v H" f
Characterize Differentiated Cell Types . . . . . . . . . . . . . . . . . . . . . . . E-5
. U! R) B3 V! `. z/ Q9 HAppendix F: Glossary and Terms+ }1 ]) G1 T9 U( L+ a! }4 ^
i. Glossary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F-1( j* K% M5 k. ~8 A
ii. Terms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F-11
. c5 a1 s' H* FAppendix G: Informational Resources9 \. @% a, N+ _) Y9 O
i. Persons Interviewed . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . G-15 ^8 l8 @8 z r5 X& Q
ii. Special Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . G-4
2 g/ b& J8 i* U6 N2 J1 miii. Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . G-5 |
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发表于 2010-4-28 00:15
