杀灭癌细胞可能是一场打鼹鼠游戏

marrowstem

欲灭肿瘤，先灭其邻！因为看起来正是包围着结肠癌的无肿瘤组织养育了最有害的癌细胞。7 C1 k* D: W# [0 H9 c+ N
      有理论认为癌细胞可以分成两种类型：普通癌细胞与癌干细胞。后者可以无限分裂，形成任何类型的癌细胞从而促进了肿瘤的生长。荷兰阿姆斯特丹大学生物学家Louis Vermeulen 说：“并非所有的癌细胞生而平等。”目前Louis Vermeulen的研究小组发现了所有的结肠癌细胞可能有着回归为干细胞的潜力，是否回归则取决于环境。
! X+ D2 A4 X7 H+ p+ [        该研究小组发现：与结肠癌干细胞相邻的结缔组织细胞分泌激发其它细胞中的一种分子通道的生长因子，该分子通道对维持干细胞样性质至关重要。只有接受了这些生长因子的癌细胞启动了这一通道，当注射到小白鼠体内时，只有这些癌细胞能够产生新的肿瘤。更进一步的是，当普通结肠癌细胞移植到其它小白鼠的结缔组织附近时，他们会转化成为癌干细胞。（参考文献：Nature Cell Biology, DOI: 10.1038/ncb2048）
- X- o% ^4 x0 X8 R% `. x  p     此提示，目标仅仅是攻击癌干细胞的治疗是不够的，这种治疗的结果可能象一场打鼹鼠游戏。Vermeulen说：“也许你应该攻击这一过程，而不是其结果。”阻止癌干细胞与其邻近组织交流可能更有效。% t: |3 G' \# ^1 C
  （《新科学家》2010年5月2日 译者：Docofsoul）

marrowstem

Killing cancer may be a game of whack-a-mole
/ t, b3 o6 s- z  \' Z1 q, R        TO KILL a tumour, go after its neighbours: it seems to be the tumour-free tissue surrounding colon tumours that fosters the cancer's most pernicious cells.9 ^9 w0 w1 S, O% u/ k. k
          One theory says that tumour cells can be divided into two types: ordinary ones and cancer stem cells, which can divide indefinitely and go on to form any kind of tumour cell, driving the growth of tumours. "Not all tumour cells are created equal," says Louis Vermeulen, a biologist at the University of Amsterdam in the Netherlands. Now Vermeulen's team has found that all colon cancer cells may have the potential to revert to stem cells and that whether they do depends on their environment.  {  U2 K9 J7 |7 M' H) I
          The team found that connective-tissue cells adjacent to colon cancer stem cells secrete growth factors that activate a molecular pathway in other cells that is vital to maintaining stem-cell-like qualities. Only cancer cells that received these growth factors switched on this pathway, and only they could seed new tumours when injected into mice. What's more, when ordinary colon cancer cells were implanted near connective tissue in other mice, they transformed into cancer stem cells (Nature Cell Biology, DOI: 10.1038/ncb2048).
/ L! [$ y6 g4 R. n( D          This suggests that treatments that merely attack cancer stem cells may not be enough - and could end up like a game of whack-a-mole. "Maybe you should attack this process, not its result," says Vermeulen. Stopping cancer stem cells communicating with the neighbouring tissue may be more effective.

prettybear

回复 1# marrowstem
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    动作好快。结果都做出来了。
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) k2 z3 L1 z$ v% P% y  看来我以前的那句话，要杀死肿瘤必须杀死肿瘤干细胞和分化细胞，并非谬论。