干细胞治疗讨论

oldmac7

一个在国外用脐带血治疗关于肝病的PROTOCOL的例子(由提供治疗的公司做提供的):# x8 A$ R* r% L7 R+ O, g" G. [% Q0 P5 x
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Stem Cell Therapy treatment Liver Disease
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% k! F$ E) R, P7 \3 h+ q* k, hstem cell therapy: Hepatitis, Cirrhosis, Cancer of the liver, Wilson's disease, Primary sclerosing cholangitis, Primary biliary cirrhosis, autoimmune disease of small bile ducts, Gilbert's syndrome, Glycogen storage disease type II.# v# t2 d' [1 S$ l+ O
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FOR IMMEDIATE RELEASE1 N2 Q& I( }: `; E, z" I$ W, }
PR Log (Press Release) – Jan 06, 2010   h8 L- J. g2 C' V3 s* G" g

5 {+ a5 H9 X2 M  T" j- m6 l; MLiver Disease Stem Cell Treatment: There is a hope apart from waiting for Liver transplant.
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6 i8 X6 k- A$ |( QStem Cell therapy for Liver disease:; T8 T$ ^1 j/ z! w( n" ?# K6 L
A selection of Conditions: Hepatitis, Non-alcoholic fatty liver disease, Cirrhosis, Cancer of the liver, Wilson's disease, Primary sclerosing cholangitis, Primary biliary cirrhosis, autoimmune disease of small bile ducts.Budd-Chiari syndrome, Gilbert's syndrome, Glycogen storage disease type II.% p% N3 H( _5 P& j* h- E# K" m
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What ever your condition, please contact us. If we feel your condtion is not effectively treatable with stem cells, we can perhaps assist you in seeking other alternatives.
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Example protocol: Stem cells: Umbilical cord blood-derived stem cells:
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CD34+ stem cells' j2 a5 j! F' d1 W  p5 X: X* i( @, v
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20,000,000 stem cells
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   * 4x CD34+ via IV injection (5,000,000 each injection)
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/ V5 x6 }7 H3 k& l  h4 x stem cell growth factor specific to condition type  b+ }/ x4 y7 z0 m- I1 J; o% q

9 g2 j' @- @3 \  `In some cases we will include very high dose hepatocyte growth factors up to 10 times before/during and after stem cell therapy.
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# u! K' d! K5 q/ W7 vDepending on the condition being treated and the level of the progression/severaity of the condition, a treatment plan will be given. This may well intail follow up treatments as our doctors will give in their view, the program which will potentially give optimum benifit to the patient. The cost of treatment can also vary slightly depending of the amount of cells, additional elements to treatment and/or if hospitalization is required.
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Example daily stem cell therapy treatment plan:- c; x1 Z* Q4 U( `

4 M8 f: g, E" G/ ], @) Z0 U8 W3 tTreatment plan:3 {0 o. [$ Q, e8 b  K. E

& g3 f, l( }5 LDay 1:3 N" p( v, p) a6 W

7 k2 B9 q: f0 I4 |( J9 D4 ~   * Medical check up
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Day 2:
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   * Stem Cells: CD34+ via IV injection : 5,000,000 stem cells
+ G# R/ R4 x, Y* b3 V. T; B3 U   * Stem Cell growth factor injection
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0 N3 O. v" p/ SDay 3:1 a9 u0 D( ]; |( O) q. h6 \
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   * Stem Cells: CD34+ via IV injection : 5,000,000 stem cells
" J. z% Q( ]' u$ x# S( N" {% o   * Stem Cell growth factor injection/ X/ |0 M+ d! v4 Q, D4 K

9 }% e. t! ?) q% @5 O, }+ qDay 4:6 I: d6 u. A$ W& r5 ~
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   * Clear
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Day 5:' \2 O: Y  @- E( H; g- X
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   * Stem Cells: CD34+ via IV injection : 5,000,000 stem cells4 m8 s6 W" _, U( p9 `2 q0 Q
   * Stem Cell growth factor injection5 P, _) Z* h  i4 R2 u* S

: p- ^$ l/ L9 @! {  |$ I( e& pDay 6:* E# t: ^( v6 g& ~
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   * Stem Cells: CD34+ via IV injection : 5,000,000 stem cells
/ n2 K" J3 a2 n2 L. p( k   * Stem Cell growth factor injection
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& d' W8 P2 _7 H* O. U% PDay 7:) [7 n0 V, I3 f8 q* }- m( u' m

" l# J, y, Z& |   * After therapy care discussion
- ?9 v& q3 d3 e. U! L   * Collection of 3 month supply of condition specific cell nutrition
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Comments and updates on patient over past 2 months:
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The Patient was in a very advanced stage of Liver disease, his SGOT level before treatment was sitting at 43 U/L and SGPT was sitting at 27 U/L, his albumin levels were very low, sitting at 2.8 g/dl. His ascites was very far advanced and causing him mobility and breathing problem. The British medical service could only offer a waiting list place for Liver Transplant.
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After administration of stem cells his ascities continued to cause him problems and we performed an abdominal tapping procedure to remove around 3 litres of fluid. This came straight back and worsened. The Patient went for a second tapping and this has now not returned.% }; ^6 J) M" [5 u3 j

8 c" w& V5 q% H9 O5 LHe is now urinating alot during the day, compared to before treatment, when he recalls maybe once or twice a day.
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Second liver function tests show SGOT sitting at 27 U/L and SGPT sitting at 19 U/L, this would suggest if interpreted in a positive manner, a lowering of liver cells being destroyed. Taking into account his increase in urination, ascites not returning and the lowering of enzyme levels indicating liver cells bursting, we should think in a positive manner.
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The Patient now has virtually no water retention and is nearly having a flat stomach, which is a very good sign in such little time.
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9 t8 d. T$ i, @+ a. j! e7 M( v0 u# M...............................................................................................................................0 l* n& n# S1 E9 |7 f# X
The Patient will undergo a second course of stem cell treatment:* n# J: r& W  z

% L/ r/ Z+ Y3 {1 v3 months:- A' H5 i# Y  a- \. D& ^

, N, n6 O8 Z1 ^Each month
$ C) ~+ c2 t8 g& j- x& ?! w( q2 P5,000,000 cd34+ stem cells5 E+ ~$ O6 `) D( O! {
5,000,000 mesenchymal stem cells
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; c3 p9 n2 c, W, |6 n2 nTreatment location: Bangkok, Thailand
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Luxury accommodation: provided for upto 9 nights# ~- {0 O) a7 |1 Y- g" b) \4 o

6 e# T; J! L- ]: h9 P1 w) rThe cost of the example protocol listed above is:7 d& F4 _& N9 E7 Z' p
$25,000- $35,000 USD depending of growth factor course and length of stay+ y% y4 f$ e0 u

oldmac7

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+ n7 S& a0 d7 W5 p0 A; R. N- _干细胞从发育潜能上分其实有很多分类:
2 X9 k; r5 ^- q( T! ]包括全能性干细胞(Totipotential)-如Zygote (fertilized egg), blastomere
4 k/ ]. ]; B2 s、多能性干细胞(Pluripotential)-如Cultured human ES cells% |' M  S, H0 H4 R# e  w2 B  b
、多向干细胞(Multipotential)-如Hematopoietic cells 、Oligopotential-如Myeloid precursor.....单能干细胞(Unipotential)-如Mast cell precursor和无分化能力干细胞(Nullipotential)-如Terminally differentiated cell e.g. Red blood cell
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干细胞来源有: 胚胎干细胞, 成体干细胞- 脐带血, 骨髓, 周边血, 脂肪和其它未发现的组织. 另外就是:诱导干细胞.
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在治疗方面, 当然最好是用全能性干细胞[如Zygote (fertilized egg)],其次就是多能性干细胞(如胚胎干细胞); 但因为要杀死一个生命, 所以在不少国家这是不允许的.
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: R$ ~& S7 M3 o- ~所以, 要治疗; 只好从成体干细胞或诱导干细胞中去着手.

lili9999

回复 2# 透明微笑
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  谢谢回复，那哪里技术好哇？可以进修去看看吗？长春、北京？6 E2 \- Q8 M- c+ _8 G
  肝素的用量是多少哇？
5 E3 H0 k9 p2 @7 ^+ Y5 J  患者的适应症呢？肝炎、一般肝硬化需要治疗吗？凝血功能对适应症有影响吗？

透明微笑

我们的治疗是用诱导后的间充质干细胞，其中有项专利，所以不便说。
7 B( V3 L+ x' I9 r5 b; m抽多少骨髓取决于培养的技术，我们只要20ML，也是专利