肝纤维化的干细胞治疗进展

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: K* V* M, K& J/ C5 ]; V; f' \丁亚楠[1,2] 潘兴华[1] 马丹[1,2] 朱向情[1] 庞荣清[1] 杨仁华[1][1]中国人民解放军昆明总医院干细胞与组织器官工程研究中心,云南省昆明市650032 [2]昆明医学院昆明总医院临床学院,云南省昆明市650031摘要：近年来国内外研究表明,在个体发育的不同阶段及不同成体组织中均存在着干细胞.肝脏内不仅存在肝源性干细胞,还存在其他组织来源的干细胞（如骨髓干细胞,胰腺干细胞等）,这些干细胞最终可以分化为成熟的肝样细胞.因此,干细胞的替代疗法为终末期肝病患者的肝纤维化治疗提供了新的思路.本文就近年来干细胞治疗肝纤维化方面的相关研究进展作一综述.& K  Y- D8 t4 s; v( ?# x
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KeyWord：Stem cell; Differentiation; Liver fibrosis; Cell therapy* k% w9 Z2 i8 i' d( o5 C: o
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关键词：干细胞 分化 肝纤维化 细胞治疗; ]0 Y6 P# A$ P% N  g

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0 [8 ~% J& B* M4 h& RProgress in treatment of liver fibrosis by stem cells Ya-Nan Ding, Xing-Hua Pan, Dan Ma, Xiang-Qing Zhu, Rong-Qing Pang, Ren-Hua Yang1.Research Center of Stem Cells, Tissue and Organ Engineering, Kunming General Hospital of Chengdu Military District of Chinese PLA, Kunming 650032, Yunnan Province, China; 2. Clinical School of Kunming General Hospital, Kunming Medical College, Kunming 650031, Yunnan Province, China
5 z4 q: p$ c$ v3 U' uAbstract：Latest studies from home and abroad indicate that stem cells exist in different adult tissues and various stages of individual development. There are stem cells not only derived from liver, but also from other tissues, such as bone marrow and pancreas in liver, which can differentiate into mature hepatocyte-like cells finally. Therefore, stem cell replacement therapy offers a new way for the clinical treatment of hepatic fibrosis in patients with end-stage liver diseases. This paper summarizes the progress in treating liver fibrosis by stem cells in recent years.
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KeyWord：Stem cell; Differentiation; Liver fibrosis; Cell therapy$ U, B4 n/ P. |* V2 o& L. J

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