最最新Stem Cells. 2010 Jun 1.

07292462

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5 T- D- N  [/ P, z- F/ U  nStem Cells. 2010 Jun 1. [Epub ahead of print]- X5 @, ?: c3 V- t: Q' s: G
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Bone Marrow Mononuclear Cells Promote Proliferation of Endogenous Neural Stem Cells Through Vascular Niches After Cerebral Infarction.! j2 B/ {  L+ k1 l; |: {- I
Nakano-Doi A, Nakagomi T, Fujikawa M, Nakagomi N, Kubo S, Lu S, Yoshikawa H, Soma T, Taguchi A, Matsuyama T.
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4 z; h) L; ?5 [8 X8 D. G! PInstitute for Advanced Medical Sciences, Hyogo, Japan 663-8501.
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Abstract' _- [& h. @; {; T
Increasing evidence shows that administration of bone marrow mononuclear cells (BMMCs) is a potential treatment for various ischemic diseases, such as ischemic stroke. Although angiogenesis has been considered primarily responsible for the effect of BMMCs, their direct contribution to endothelial cells (ECs) by being a functional elements of vascular niches for neural stem/progenitor cells (NSPCs) has not considered. Herein we examine whether BMMCs affected the properties of ECs and NSPCs, and whether they promoted neurogenesis and functional recovery after stroke. We compared intravenous transplantations 1x10 BMMCs and PBS in mice 2 days after cortical infarction. Systemically administered BMMCs preferentially accumulated at the post-ischemic cortex and peri-infarct area in brains; cell proliferation of ECs (angiogenesis) at these regions was significantly increased in BMMCs-treated mice compared with controls. We also found that endogenous NSPCs developed in close proximity to ECs in and around the post-stroke cortex, and that ECs were essential for proliferation of these ischemia-induced NSPCs. Furthermore, BMMCs enhanced proliferation of NSPCs as well as ECs. Proliferation of NSPCs was suppressed by additional treatment with endostatin (known to inhibit proliferation of ECs) following BMMCs transplantation. Subsequently, neurogenesis and functional recovery were also promoted in BMMCs-treated mice compared with controls. These results suggest that BMMCs can contribute to the proliferation of endogenous ischemia-induced NSPCs through vascular niche regulation, which includes regulation of endothelial proliferation. In addition, these results suggest that BMMCs transplantation has potential as a novel therapeutic option in stroke treatment.
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PMID: 20517983( Q# d& A* G5 M8 O- g" D( z8 e
http://www.ncbi.nlm.nih.gov/pubmed/20517983

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