一篇关于MiRNA 跟肿瘤关系的文章， 想跟大家讨论

ganxibao11

MicroRNA expression profiles classify human cancers （title）$ U! t/ O; z/ f0 Q* }8 S% g
Abstract
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Recent work has revealed the existence of a class of small non-coding RNA species, known as microRNAs (miRNAs), which have critical functions across various biological processes1, 2. Here we use a new, bead-based flow cytometric miRNA expression profiling method to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers. The miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours. We observe a general downregulation of miRNAs in tumours compared with normal tissues. Furthermore, we were able to successfully classify poorly differentiated tumours using miRNA expression profiles, whereas messenger RNA profiles were highly inaccurate when applied to the same samples. These findings highlight the potential of miRNA profiling in cancer diagnosis.) X0 N, e3 a2 T* O
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ganxibao11

Yeah， diagnosis is the first step toward therepies. Moreover, miRNA has always been the most prospective choice for gene therapy.

ganxibao11

Eventhough, one miRNA may have many targetted mRNAs. The possibility is that all these targetted mRNA may work cooperatively rather than separately. This can explain why knocking down one miRNA can induce certain phenotype.

ganxibao11

Eventhough, one miRNA may have many targetted mRNAs. The possibility is that all these targetted mRNA may work cooperatively rather than separately. This can explain why knocking down one miRNA can induce certain phenotype.

ganxibao11

Eventhough, one miRNA may have many targetted mRNAs. The possibility is that all these targetted mRNA may work cooperatively rather than separately. This can explain why knocking down one miRNA can induce certain phenotype.

ganxibao11

Sorry, there happened to have an internet p

ganxibao11

Sorry, there happened to have an internet problem