EMT和肿瘤转移的新观点：EMT and cell cooperativity in metastasis

饶冠华

Cancer Res. 2009 Sep 15;69(18):7135-9. Epub 2009 Sep 8.
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9 E0 p/ y! _7 y4 M6 Z+ o+ vEpithelial-mesenchymal transition and cell cooperativity in metastasis.
( @; T* Q" N& q0 t( [' q% cTsuji T, Ibaragi S, Hu GF.
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6 Z/ |" w8 a  c6 g' fDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.' N) E3 b6 X: U* {5 s* ]

9 x6 T  o) n$ a+ tAbstract  p  \4 n, c% Q4 t# l
The role of epithelial-mesenchymal transition (EMT) in metastasis remains controversial. EMT has been postulated as an absolute requirement for tumor invasion and metastasis. Three different models including incomplete EMT, mesenchymal-epithelial transition (MET), and collective migration have been proposed for the role of EMT in cancer invasion and metastasis. However, skepticism remains about whether EMT truly occurs during cancer progression, and if it does, whether it plays an indispensible role in metastasis. Our recent findings suggest that EMT cells are responsible for degrading the surrounding matrix to enable invasion and intravasation of both EMT and non-EMT cells. Only non-EMT cells that have entered the blood stream are able to re-establish colonies in the secondary sites. Here, we discuss an alternative model for the role of EMT in cancer metastasis in which EMT and non-EMT cells cooperate to complete the entire process of spontaneous metastasis.
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PMID: 19738043 [PubMed - indexed for MEDLINE]PMCID: PMC2760965 [Available on 2010/9/15]5 f2 O. ?+ }  |9 U

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exin11

谢谢

lixiaodong

Thanks for sharing.

flydayzhu

谢谢~

张也行

谢谢分享

ambassador

摘抄重点：
9 \6 _" ~' R9 r9 @$ BOur recent findings suggest that EMT cells are responsible for degrading the surrounding matrix to enable invasion and intravasation of both EMT and non-EMT cells. Only non-EMT cells that have entered the blood stream are able to re-establish colonies in the secondary sites.

wzx6660

先学习一下

Caixiqiang

Only non-EMT cells that have entered the blood stream are able to re-establish colonies in the secondary sites.

ttyjimmy

转换与不转换 that is a question

sosososo007

谢谢！