《细胞-干细胞》[Cell Stem Cell]2010年9月3日出版pdf全文

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3 September, 2010 Volume 7, Issue 3
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8 G/ E, k4 Z9 r) G3 c+ SEditors' Notes
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( J2 e" U: w- d: N2 W+ i: QPreviews9 _) T0 k8 J/ ^, q; d
Cancer Cell of Origin: Spotlight on Luminal Progenitors
/ O1 S) W0 a+ E2 xChristine L. Chaffer, Robert A. Weinberg# A& Q2 e' u$ d! j4 C- U( o' P
Microarraying for Mechanosensivitity
; `, `. e2 a/ L, ]: _1 KDavid V. Schaffer% r9 h" i6 S7 s3 t+ x* Z. m
The STATs on Naive iPSC Reprogramming5 R! j4 |, r5 n$ U' m  X
Jacob H. Hanna
! R: }2 C1 b$ h% R/ BHypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword2 b3 _# j- j% k$ d7 T) s
Patrick J. Pollard, Kamil R. Kranc) L$ N3 l1 A- s4 b, a
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Brief Report
9 r, n# G' K8 w' h; FTumor-Initiating Cells Are Rare in Many Human Tumors$ u1 ?2 l- ?% A' q. D( ]% n6 [
Kota Ishizawa, Zeshaan A. Rasheed, Robert Karisch, Qiuju Wang, Jeanne Kowalski, Erica Susky, Keira Pereira, Christina Karamboulas, Nadeem Moghal, N.V. Rajeshkumar, Manuel Hidalgo, Ming Tsao, Laurie Ailles, Thomas K. Waddell, Anirban Maitra, Benjamin G. Neel, William Matsui! R9 |& b$ g+ R6 i) I4 h' n, k# }
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Forum
; R: c3 E7 O& m: O8 A9 d) dThe Orphan Drug Act and the Development of Stem Cell-Based Products for Rare Diseases
# N  J4 s& l3 aScott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté# l- F1 a* I/ l0 {* }$ x
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Reviews# ?3 }: p$ D! ^: g  h
Polycomb Group Proteins Set the Stage for Early Lineage Commitment6 O9 t$ x" ?# T1 T2 Y; t( |4 }/ ]
Lauren E. Surface, Seraphim R. Thornton, Laurie A. Boyer
$ n6 z2 z, a! G# M) w& DPolycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer* |: G6 z* x! J, `0 o! R' w1 z
Martin Sauvageau, Guy Sauvageau) k# x, n1 ^5 @  `/ f

4 {0 A  |2 s* @6 ?ISSCR: President's Note
% g# ~3 p& ~7 a$ `: `  g) EToward a Knowledge of Causes
6 o. P- a! Q% F- ?$ ?4 M; SElaine Fuchs6 g1 `( H" O( x
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Articles
" J0 _6 T& O. H' `+ \4 E4 Q; K5 OStat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency3 s( g, {, |  l, H. Z3 ?5 x; u6 U
Jian Yang, Anouk L. van Oosten, Thorold W. Theunissen, Ge Guo, Jose C.R. Silva, Austin Smith$ ~  @, u) G) {; V7 f) J/ b
Female Human iPSCs Retain an Inactive X Chromosome4 h7 \5 l" s+ k
Jason Tchieu, Edward Kuoy, Mark H. Chin, Hung Trinh, Michaela Patterson, Sean P. Sherman, Otaren Aimiuwu, Anne Lindgren, Shahrad Hakimian, Jerome A. Zack, Amander T. Clark, April D. Pyle, William E. Lowry, Kathrin Plath$ A3 \4 F5 q$ p( l) V
Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells3 k9 x4 R, P  E! Z
Keriayn N. Smith, Amar M. Singh, Stephen Dalton
# L* l) J! j3 _7 u6 d* ^Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation
. L( `1 O2 v" G, E. I( T; PMirza Peljto, Jeremy S. Dasen, Esteban O. Mazzoni, Thomas M. Jessell, Hynek Wichterle( v5 u! T8 v7 E) ?6 Y, k0 O
Regulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling
; X9 D  F; y1 S. z, v! y) ESacri R. Ferron, Natividad Pozo, Ariadna Laguna, Sergi Aranda, Eva Porlan, Mireia Moreno, Cristina Fillat, Susana de la Luna, Pilar Sánchez, María L. Arbonés, Isabel Fariñas8 u: `0 @* p# w% W2 D# K8 \
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche; _; r: p6 z5 p# d8 c
Tugba Simsek, Fatih Kocabas, Junke Zheng, Ralph J. DeBerardinis, Ahmed I. Mahmoud, Eric N. Olson, Jay W. Schneider, Cheng Cheng Zhang, Hesham A. Sadek
3 l" F1 L4 R# ^- U- [  tRegulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells# y0 M+ K5 @7 x) ^2 D( a
Keiyo Takubo, Nobuhito Goda, Wakako Yamada, Hirono Iriuchishima, Eiji Ikeda, Yoshiaki Kubota, Haruko Shima, Randall S. Johnson, Atsushi Hirao, Makoto Suematsu, Toshio Suda
5 @1 [6 k4 {& MFeatured Article
: J$ q* Z1 |  \& N' _7 cBRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells5 j7 b  G$ s8 T* A) P* j
Gemma Molyneux, Felipe C. Geyer, Fiona-Ann Magnay, Afshan McCarthy, Howard Kendrick, Rachael Natrajan, Alan MacKay, Anita Grigoriadis, Andrew Tutt, Alan Ashworth, Jorge S. Reis-Filho, Matthew J. Smalley# W# [( k0 }& b+ I2 F# s
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