科学家发现干细胞活力因子blebbistatin（附原文）

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很好的文章，谁能把题目翻译一下，要是摘要也翻译就更好了。  
; o6 j& `# J0 Q' r4 S* l' k& v Non-muscle myosin II regulates survival threshold  of pluripotent stem cells
" S) w& j+ W+ y* N. v$ b' s Human pluripotent stem (hPS) cells such as human embryonic stem (hES) and induced " f* T7 w$ q; f* [
pluripotent stem (hiPS) cells are vulnerable under single cell conditions, which hampers 3 Y6 [# G' d: G5 @8 n: G& S( [
practical applications; yet, the mechanisms underlying this cell death remain elusive. In this
" N" F( e# @6 w0 b3 p, }& t1 Gpaper, we demonstrate that treatment with a specifi  c inhibitor of non-muscle myosin II (NMII),
7 y. C* H6 }+ W, g! K0 v5 _blebbistatin, enhances the survival of hPS cells under clonal density and suspension conditions,
; z; \1 T1 \; z% ]and, in combination with a synthetic matrix, supports a fully defi  ned environment for self-
6 m. A1 x7 Y; Krenewal. Consistent with this, genetically engineered mouse embryonic stem cells lacking an
; ]# S6 k1 _% c6 Eisoform of NMII heavy chain (NMHCII), or hES cells expressing a short hairpin RNA to knock   B7 ~8 q) C! n  |
down NMHCII, show greater viability than controls. Moreover, NMII inhibition increases the ' ~5 F7 P* w; g8 w- x1 N  h
expression of self-renewal regulators Oct3 / 4 and Nanog, suggesting a mechanistic connection
0 ]- C5 J6 v4 c6 |! a% [between NMII and self-renewal. These results underscore the importance of the molecular
+ O; P2 h$ b! d, y* v. bmotor, NMII, as a novel target for chemically engineering the survival and self-renewal of
, W! I) H9 Z& w  Y  }6 b+ ZhPS cells.