能否将肿瘤细胞转化成干细胞！

susuloveq

回复 sunsong7 的帖子
1 C' j$ g! U$ ?; P0 ]0 M
# \  Z' o, v  m$ ^9 |# p" z还真的有啊？？观望

一枝独秀

最近刚刚在论坛里看到niche reprograming的描述，站在这个立场上，个人就觉得是完全可能的；而且最近Robert A. Weinberg　在ＰＡＮＳ（March 2, 2011）的研究结果显示，正常或非干性肿瘤细胞可以自发的转变为干细胞样细胞，在此过程中，癌基因的 转化可起到加速作用

新疆八钢

准确的说是将肿瘤干细胞转化为正常干细胞，肿瘤组织中不是所用的细胞都具有干细胞特性，但是，以目前科学对肿瘤干细胞的认识来说，只在血液系统恶性疾病中，这得到验证，在实体恶性肿瘤领域，还需要长期的研究与实验验证

qhb2010

很有意思的一个话题！！

angeljianguo

回复 sunsong7 的帖子/ q( W# c5 a  i( B/ [" [# ?+ y

1 p- Q; L6 H+ v: [, ]关注中

sunsong7

Public release date: 8-Jul-2010
- S+ U+ ]& \7 A6 NContact: Jenny Song) Q& \$ d8 ^+ L( j* m
jsong@waxmancancer.org. i9 ?, j1 l. y9 a) T7 F  Y5 o, b
212-867-45025 ~% u5 I5 F% B
Samuel Waxman Cancer Research Foundation ; Y. A0 ]6 ~+ l! F0 @4 L0 a! G4 H2 @
! L9 |3 P& |( U8 o7 C% k
Scientists reprogram triple-negative breast cancer cells to respond to tamoxifen（科学家重新编程三重阴性乳腺癌细胞来响应他莫西芬）8 l7 O1 M2 b0 f' ~
Using a small molecule decoy, investigators funded by the Samuel Waxman Cancer Research Foundation have managed to block protein interactions and induce epigenetic reprogramming in human and mouse breast cancer cells, essentially changing the gene expression of breast cancer cells to behave in a more normal manner. The research illustrates what may perhaps become an effective targeted epigenetic therapy in breast cancer. Interestingly, the targeted treatment showed exciting results in triple-negative breast cancer cells, reverting their function and appearance, and sensitizing them to tamoxifen and retinoids.
' E( C- j& Y# y2 q7 B8 P
- b/ `; }: H5 ~8 O0 NBy introducing a small peptide, called the SID decoy, to interfere with protein binding in the Sin 3 PAH2 domain, scientists reduced the growth of triple-negative cancer cells by 80 percent. The decoy also blocked cancer cell invasion, which may shed light on preventing metastasis. The study was published in the June 29 print edition of the journal of the Proceedings of the National Academy of Sciences. 5 n# d! f# ^; X+ d$ a5 }$ e
; G) E4 s5 K% C" k) m
Triple-negative breast cancer is an aggressive form of breast cancer more commonly diagnosed in young women, African-American women and women with BRCA-1 mutated cancers, said medical oncologist Samuel Waxman, M.D., the study's senior author. Currently, the only treatment options that women with triple-negative breast cancer have are radiation therapy, surgery and chemotherapy. Women with triple-negative breast cancer do not respond to hormonal therapy or Herceptin and have a higher recurrence rate after chemotherapy.
6 z" p0 d9 G7 i# F9 L. C8 Y
4 B5 e3 J0 R2 B3 E% M( E) E. w0 J"Hopefully, this breakthrough research means we can expand treatment options for women with triple-negative breast cancer and give them a chance at anti-estrogen hormonal therapy," said Dr. Waxman, a professor in the department of Hematology and Oncology at Mount Sinai Medical Center in New York City and the scientific director of the Samuel Waxman Cancer Research Foundation.$ e( p7 X% S7 Q' Z0 }  K: B8 l

  H: _4 O8 G8 K2 Y. d8 g3 jArthur Zelent, Ph.D., a co-author of the study, said researchers plan to investigate small molecules that are predicted to have the same effect as the decoy peptide. "This could form the basis for a new class of targeted, epigenetic drugs in breast cancer," said Dr. Zelent, a team leader at The Institute of Cancer Research in the United Kingdom.6 @( t2 }6 R1 y( E; n/ z
! T7 N9 ]7 e$ A  O5 l% k8 B
Elizabeth Woolfe, the executive director of the Triple Negative Breast Cancer Foundation, said though the study's results are too preliminary to make a clinical impact for cancer survivors today, she added, "The findings offer encouraging results that could lead to other promising research and the potential for new therapeutics for women facing triple-negative breast cancer." + e. N: i9 P7 @& |; d% h
* V$ F6 x: _% s8 o
0 L& I' a; N$ A# t" V
###
7 g7 s5 |8 }- P" \
# j, j0 y) N' r% f' r! R4 hAbout the Samuel Waxman Cancer Research Foundation% q  {* h4 ~4 q, a4 n/ v( ?

& o3 O' |# ]1 WThe Samuel Waxman Cancer Research Foundation is an international organization dedicated to curing and preventing cancer. The Foundation is a pioneer in cancer research, focusing on uncovering the causes of cancer and reprogramming cancer cells.
- z$ Y: y5 v9 |5 I& X3 G
2 h: _2 J0 W9 p# ]4 l* MWe dedicate ourselves to delivering tailored, minimally toxic treatments to patients. Our mission is to eradicate cancer by bridging the gap between lab science and the patient.5 z) f; N* a+ w! y$ y& j

% n4 Z7 F- d/ Q% \- D3 y7 Q$ y) XThrough our collaborative group of world-class scientists, the Institute Without Walls, investigators share information and tools to speed the pace of cancer research. Since its inception in 1976, the SWCRF has awarded more than $70 million to support the work of more than 170 researchers across three continents., u! D* V4 E6 J6 j8 s* R
  k- ^* }# P* c& w( o+ ~' ]
For more information, visit www.waxmancancer.org # z* B! D; w/ Q0 ^/ W/ G0 x
) {& a$ B' T$ ?5 C

sunsong7

还真有人将癌细胞重编程为多能干细胞？. |. c  W/ n4 l: L) c/ G- u  B1 ]

. }2 h) u3 p& [: F7 F& u4 G) o附文采用逆转录病毒载体转导 Oct4、Sox2、Klf4 和 c-Myc 四个因子，来重编程肝癌细胞 HepA1-6为 iPS细胞。通过免疫荧光和RT-PCR实验证明诱导出的细胞表达多能干细胞相关的标记。

embryonic12

从表观遗传学角度说，这是可以的，也是很有意义的。但是癌细胞的基因组已发生广泛的变异，如非整倍体，重复，缺失等等。这样即便实现了，所得细胞也应是一种异常的多能性细胞呀

mnxn

将癌细胞直接转变为干细胞，这确实有点太过跨越式了，为什么不就近一点，先利用癌细胞呢？比如，癌细胞本身是具有无限增值能力，那我们把它拿到体外培养，作为宿主细胞，进行产物生产，就跟大肠杆菌和酵母菌一样。
- A5 z  e  E; M* m% X/ z当然，癌细胞是淘气而不受约束的，在由正常细胞转化为癌细胞之后，原细胞有一定程度的退化，功能的丧失，这一点有些恶劣。
% q7 |6 c* l/ W- @9 W; y8 l/ I将癌细胞变为生产机器，我想这应该比直接变为干细胞，容易一些，也安全一些。- ]/ N3 h- z8 S5 R( E4 c

conquer87

癌细胞确实和干细胞有一些相似性，感觉是兄弟俩，不过一个很善良，而另一个变坏了