Nature Reviews——STEMCELL精彩壁挂！

sunsong7

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% I4 U2 A, C- e' e% t$ sAntigen Processing and Presentation Wallchart
9 v; _0 g6 _- j' O6 Y2 ?5 j9 cPamela Wearsch and Peter Cresswell7 s' o7 k; Y! c5 d% l
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+ Q: R" H# A, p" P: `! aThe process by which antigen-presenting cells digest proteins from inside or outside the cell and display the resulting antigenic peptide fragments on cell surface MHC molecules for recognition by T cells is central to the body's ability to detect signs of infection or abnormal cell growth. As such, understanding the processes and mechanisms of antigen processing and presentation provides us with crucial insights necessary for the design of vaccines and therapeutic strategies to bolster T-cell responses.This poster provides an updated overview of the intracellular pathways and mechanisms by which antigens are captured, processed and loaded onto MHC class I, class II and CD1d molecules for presentation to T cells.
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& G* T) [9 v# N, eAssays for Human Mammary Stem and Progenitor Cells  F7 E' c2 _1 n+ h* a
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This new wallchart provides information on the hierarchy of mammary epithelial cell differentiation and some of the functional assays that can be used to study mammary stem and progenitor cells.
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Cell Type Frequency Wallchart3 |7 d5 r4 B1 Q5 s6 A
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This wallchart provides frequencies of cell types in human peripheral blood and protocols for processing blood.
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Cord Blood Wallchart
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This wallchart is a colorful guide to hematopoietic colonies derived from human cord blood progenitors.
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Mouse Hematopoietic Progenitors Wallchart
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This new wallchart features photographs of a variety of representative colonies derived from mouse hematopoietic progenitors, comprehensive descriptions to assist in colony identification and plating concentration guidelines for quick reference.8 ~& r3 W3 h! A( y& P$ D# g9 a
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Natural Killer Cells Wallchart8 {7 h2 x! Z$ d
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Eric Vivier and Sophie Ugolini
; G0 Q9 Y9 [7 L- A" ~: MNatural killer (NK) cells were identified in 1975 as lymphocytes of the innate immune system that can kill tumour cells. Since then, NK cells have been shown to kill an array of ‘stressed’ cells and secrete cytokines that participate in shaping adaptive immune responses. A key feature of NK cells resides in their capacity to distinguish stressed cells (such as tumour cells, infected cells and damaged cells) from normal cells.8 a1 g, e& e1 j' Y  h' s

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8 i+ H" S6 }8 m6 ~+ E, e& B1 V, @Neural Stem Cells Wallchart
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* X0 ~8 L2 u+ P3 VVirginia Mattis, Soshana Svendsen, Dhruv Sareen and Clive Svendsen5 c) P' {+ {8 e4 k$ s
Neural stem cells are capable of self-renewal and can generate neurons, astrocytes and oligodendrocytes. During nervous system development, NSCs within the primitive neural ectoderm give rise to neural progenitors, which rapidly become regionally and temporally specified, first generating large projection neurons and later small interneurons and glia.
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Pluripotent Stem Cell Biology Wallchart+ ^1 O: g8 u: b. h! L

" N' l, j$ d! H! ~( hChristopher Lengner and Rudolf Jaenisch- W0 B6 \4 X$ S" g3 i' ]
Pluripotent cells offer great promise to the future of regenerative medicine and tissue engineering.  Nuclear transfer, direct reprogramming and cell fusion can be used to experimentally induce pluripotency in somatic cells. To date, no naturally occurring pluripotent cell has been identified in the mammalian soma, and cells with pluripotent potential in the early embryo or germ lineage are difficult to isolate from patients. This makes methods of experimentally induced pluripotency in readily available somatic cells (such as skin biopsies) invaluable for the generation of patient-specific stem cells.+ n5 A* I9 Y' D( g6 p1 m0 V+ y( m

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Regulatory T cells Wallchart   ?5 ^/ d6 h( [- \3 b

; @8 k$ W& [: h" ^( t: SEthan Shevach and Todd Davidson 3 q5 o+ |6 E+ ]# O% [
Regulatory T cells are vital for keeping the immune system in check, helping to avoid immune-mediated pathology and unrestricted expansion of effector T cell populations. Accordingly, regulatory T cells have been the focus of extensive research over the past few years, and this has revealed diverse roles for those cells in numerous diseases, including autoimmunity, allergy, microbial infection and cancer. We now have a good understanding of how they arise, how they are maintained, how they exert their suppressive effects and how they might be harnessed for therapeutic intervention. This poster provides an updated overview of the development, phenotype and functions of regulatory T cells, in particular those subsets that express the transcription factor forkhead box P3 (FOXP3). The poster is freely available thanks to support from STEMCELL Technologies.
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cantonchn

真好！有没有MSC和CIK的

zhaoyuwei

nice work) |" _4 U6 J9 l4 r- T1 A/ O5 U

懵懂干细胞

不得不赞一个！！

ssyt

去STEMCELL下~

亨弗莱

很精美

BNJN

不错，先下了

随风的天使

真好，谢谢。

sunsong7

From teratomas to embryonic stem cells: discovering pluripotency9 j* d5 n# `* U! U! p
Peter W. Andrews and Paul J. Gokhale
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6 f( y. q& l/ p$ W3 @4 vArticle bodyThis year marks the thirtieth anniversary since mouse embryonic stem (ES) cells were first isolated from blastocysts. This paved the way to the first targeted knockouts of genes in mice, which provided a crucial tool for studying mouse development and founded a new field of stem cell research. Today, researchers are able to generate induced pluripotent stem (iPS) cells from somatic cells, which might have important clinical applications.1 V& N0 h6 }  w# e
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This Poster by Peter W. Andrews and Paul J. Gokhale provides a timeline overview of the history of pluripotency, starting from early studies of teratocarcinomas in 1954, which preceded the isolation of mouse and human ES cells, and ending with the generation of iPS cells. In doing so, it highlights how our understanding of the pluripotent state has evolved over almost 60 years.
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The Poster is freely available thanks to support from Abcam
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sunsong7

The identity and properties of mesenchymal stem cells
$ n+ Y' X' I1 R" Y5 C$ T& _- ]; vCésar Nombela-Arrieta and Leslie E. Silberstein- x" d* u% s9 A/ B: H# I

: H7 g8 G- i4 A: k1 ]$ M& jArticle bodyMesenchymal stem cells (MSCs) are multipotent progenitor cells that were originally identified in the bone marrow stroma, where they regulate key stages of haematopoiesis. They have since been identified in other anatomical locations, although their physiological roles remain unclear. MSCs can be expanded in vitro and, under appropriate conditions, can give rise to several cell types, including bone and fat precursors. The in vitro-expanded cells have remarkable immunoregulatory properties and effects on tissue repair; because of this, their potential use as therapeutic agents in vivo is being extensively studied.! b" Y7 x8 n3 S, K+ t/ `- F, T2 ]
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This Poster by César Nombela-Arrieta and Leslie E. Silberstein provides an overview of the identity of MSCs in vivo and the effects of their in vitro-expanded progeny, and highlights key questions that remain in the field regarding the biology of these elusive cells.
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% |3 L' q7 O8 J" q% Y4 [, [, iThe Poster is freely available thanks to support from STEMCELL Technologies Inc.
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