最新研究发现细胞爆炸可引发瞬间癌症

tpwang

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感谢介绍与原文。翻译介绍的比较简单与“媒体化”，呵呵。7 D) Q8 |0 i: j
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We would predict that inthe case of chromothripsis, the overwhelming
/ E& Y3 s. e) w" }! Gmajority of cells suffering such spectacular genomic damage would ! r: l; a$ l( X
either die or acquire more detrimental than advantageous variants.
$ I+ {0 c1 D2 C4 c. p( X- I, }However, very rarely, a cell might acquire one or more cancercausing# K* {6 u; Y5 E* p1 [
lesions from such an event and this clone would then have taken a 9 w* ]7 Q) S# J. d
considerable leap along the road to cancer. There would still be the " P9 B, {5 s, B, [$ u9 s
need for additional mutations in cancer genes, exemplified by the
: K8 q9 x2 o+ W, |second hits in CDKN2A seen in the chordoma and thyroid cancer
  Q: W' K1 X0 b0 jsamples (Figure 7), but we might anticipate the emergent tumor
; ^3 J2 `: ], Xhaving shorter latency.. w3 w* J- `6 S4 R9 e
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看起来是说特定过程的一个灾难性事件导致rearrangements，修复" Y( @. l; o5 n1 ^+ d" D
过程太急太乱，然后再遇到进一步的突变，应该说是一个灾难性
% K8 s9 c- z4 Q3 }& k) U& \$ B事件引发的加速癌变过程。  m# G% R# L" o. c
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The genomic regions involved in each example are sharply circumscribed,/ t! A. W$ c9 a/ l8 h# i
whether it be a whole chromosome, a chromosome arm or a region of just
) V, V: f5 R3 r0 C$ O. u6 p: Da few megabases within a chromosomal band. It seems likely that the insult
& _0 S. `: `/ K1 k, `occurs while the chromosomes are condensed for mitosis.  T0 F9 q/ ]3 e8 |) I& o" C/ ~
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这个可能情景是否有延伸的意义。。。