最新研究发现细胞爆炸可引发瞬间癌症

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! [  ]4 H: D6 q  F( L( a' k感谢介绍与原文。翻译介绍的比较简单与“媒体化”，呵呵。
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% B' B4 m+ L( ^( oWe would predict that inthe case of chromothripsis, the overwhelming
- T8 U) i4 u. D& o! Cmajority of cells suffering such spectacular genomic damage would 7 `7 N' _" I" Y! i4 m' ?' [) s
either die or acquire more detrimental than advantageous variants.8 }+ \6 ^. V, h3 ^; |4 b
However, very rarely, a cell might acquire one or more cancercausing
* n; L( ?/ U& b% u; v+ V  {lesions from such an event and this clone would then have taken a ) w! O# T4 |8 b( D% G/ q% |
considerable leap along the road to cancer. There would still be the 8 Z6 ^% t( z5 h$ G5 \
need for additional mutations in cancer genes, exemplified by the
8 [/ _( b) J' s4 j" \3 ?second hits in CDKN2A seen in the chordoma and thyroid cancer
% V  Q: o$ l- }) ~0 j- csamples (Figure 7), but we might anticipate the emergent tumor
$ S! [: J/ B( H; U! i0 ]4 Dhaving shorter latency.
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看起来是说特定过程的一个灾难性事件导致rearrangements，修复
  L0 Y1 F1 W6 H过程太急太乱，然后再遇到进一步的突变，应该说是一个灾难性
$ l6 n# H0 q( R1 L* P6 C( f8 q事件引发的加速癌变过程。
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" v. |3 C. q' T+ [: X+ g& GThe genomic regions involved in each example are sharply circumscribed,% c1 @  S: E) u3 y
whether it be a whole chromosome, a chromosome arm or a region of just
, }" O& A: u' U4 Z+ E4 ma few megabases within a chromosomal band. It seems likely that the insult , w7 h% U# t% `. u" o
occurs while the chromosomes are condensed for mitosis.& l4 c/ {/ P- I2 ^( z# p3 Y
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这个可能情景是否有延伸的意义。。。