最新研究发现细胞爆炸可引发瞬间癌症

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* v" p& Q4 T, l" s( Y感谢介绍与原文。翻译介绍的比较简单与“媒体化”，呵呵。# C2 @* r! C5 M* @- I& n4 ~

! r; y9 }' J% w1 w$ W) b" tWe would predict that inthe case of chromothripsis, the overwhelming + T7 w! a7 E7 w+ A: l2 F
majority of cells suffering such spectacular genomic damage would 8 T  O2 b4 X( E
either die or acquire more detrimental than advantageous variants.
8 J# ~. D  n3 J! R2 i' AHowever, very rarely, a cell might acquire one or more cancercausing
1 \3 z% ^! d! w2 Y& L0 ?4 Y9 Jlesions from such an event and this clone would then have taken a 0 _+ N, Y: R( C  }
considerable leap along the road to cancer. There would still be the
( Z+ q( R+ [) F* y* B& Xneed for additional mutations in cancer genes, exemplified by the
  @+ T  I) Y4 M& R, J0 W1 esecond hits in CDKN2A seen in the chordoma and thyroid cancer 6 ]2 g, E% W( s* A
samples (Figure 7), but we might anticipate the emergent tumor " o" O8 T/ x2 ~' \3 {, K: x
having shorter latency.7 m, ]: a' C# c+ m( Q

, v2 w. M$ H  D( E/ C- c看起来是说特定过程的一个灾难性事件导致rearrangements，修复1 j6 ?# f$ L( D' j6 {
过程太急太乱，然后再遇到进一步的突变，应该说是一个灾难性
' L6 u  l$ l' u事件引发的加速癌变过程。, ^% V, o: G- ?% H7 e6 i

! {' c3 `' d4 z: G; q- xThe genomic regions involved in each example are sharply circumscribed,8 c+ }7 ~9 G1 }$ @
whether it be a whole chromosome, a chromosome arm or a region of just ) M" R/ [" Q3 @  f- f
a few megabases within a chromosomal band. It seems likely that the insult
* _# T/ d" ]3 }- h* Soccurs while the chromosomes are condensed for mitosis.
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! N$ }& P! ]( C这个可能情景是否有延伸的意义。。。