PDF电子书：Epigeneticsts in Biology and Medicine

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本书分多个专题论述了疾病发生和表观遗传修饰的关系，包括DNA甲基化、组蛋白修饰以及非编码RNA之间的关系，对疾病产生和环境之间的关系也进行了论述，值得进行表观遗传研究的人员参考。
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% w6 p' ~$ P9 W- }8 GGenetics alone cannot explain human variation and disease. Humans with the same DNA sequence, such as monozygotic twins, and cloned animals frequently present different phenotypes and degrees of sickness penetrance. The increasingly popular term epigenetics embodies a partial explanation of both phenomena. First introduced by C.H. Waddington in 1939 to name “the causal interactions between genes and their products, which bring the phenotype into being,” it was subsequently defined as those heritable changes in gene expression that are not due to any alteration in DNA sequence. The best-known epigenetic marker is DNA methylation. From the initial characterization of global hypomethylation of human tumors and the first hyper- methylated tumor suppressor, to the DNA methylation silencing of microRNAs, the ongoing human epigenome projects, and the clinical approval of therapies with DNA demethylating agents and histone deacetylase inhibitors, epigenetics has seized the attention of biomedical researchers. The scenario is further enriched because DNA methylation occurs in a highly complex chromatin network mediated by histone modifications, which are also disrupted in human diseases. Aberrant epigenetic pat- terns go beyond oncology to touch a wide range of fields of biomedical (immunol- ogy, neurology, metabolism, imprinting, cardiovascular, etc.), scientific (machineries for transcriptional activation and repression, high-order organization of DNA, etc.), and industrial (animal and yeast models, agriculture, nutrition) knowledge that have an impact on our lives.* r' h# W2 c2 l- A3 K9 I' H
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