iPS、胚胎干与直接转分化的“三国演义”

zhenhua

回复 tpwang 的帖子" m4 l1 ^7 X9 n+ l
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人ES无法用四倍体互补实验。3 }: a' g9 j+ R# q% F0 R& s/ H4 h
最近Rudolf Jaenischa发了一篇Human embryonic stem cells with biological and. T0 D8 [9 [3 m- ^# O* i
epigenetic characteristics similar to those of mouse ESCs的文章。/ z6 c/ ^; l, p8 A: M# k! @
通过ectopic induction of Oct4, Klf4, and Klf2 factors combined with LIF and inhibitors of glycogen synthase kinase 3β2 J+ N: ^+ c7 I% ^
(GSK3β) and mitogen-activated protein kinase (ERK1/2) pathway，是hES与mES达到比较类似的程度。$ c. }) T2 ~5 B( h+ l8 s  I
那可不可以利用这种方法，来验证hES和hiPS多能性的标准？