iPS、胚胎干与直接转分化的“三国演义”

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人ES无法用四倍体互补实验。, h7 w# G/ f' }
最近Rudolf Jaenischa发了一篇Human embryonic stem cells with biological and
8 L- C( j8 U" J/ i, M4 ]epigenetic characteristics similar to those of mouse ESCs的文章。6 x: G. T* l" u5 N
通过ectopic induction of Oct4, Klf4, and Klf2 factors combined with LIF and inhibitors of glycogen synthase kinase 3β" b8 G3 B* T; O
(GSK3β) and mitogen-activated protein kinase (ERK1/2) pathway，是hES与mES达到比较类似的程度。
% N0 s  F- U$ S/ M7 [那可不可以利用这种方法，来验证hES和hiPS多能性的标准？