CD44算不算肿瘤干细胞的标记分子？

deron

主题：CD44：肿瘤起始细胞能从一种大量表达的分子中受益吗？' Q7 X1 M1 m+ g  [- o

& ]4 Q, e8 ]6 M" u  ?6 t说明：原文来源自Nat Rev Cancer.，由干细胞之家新闻小组成员deron翻译（转帖请注明）。这是一篇带有质疑色彩的综述吧？尚无原文3 z" i" W$ M. H/ A3 V

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  s1 z3 ~8 ^) l) U一种大量表达的分子能成为肿瘤起始细胞（CIC——又称肿瘤干细胞）的可靠标记分子吗？肿瘤起始细胞在肿瘤实体细胞中含量较少。CD44已经成为几种造血和内皮起源的恶性肿瘤CIC标记分子。这是因为分子普遍表达的偶然一致，还是由于CD44因能满足CICs特性要求（例如自我更新、壁龛准备、内皮间充质转移和抗凋亡）而优先表达呢？' {" k6 ^  `; K+ {

/ c/ l( K$ Y/ c8 _4 [6 R) x原摘要：Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells (CICs; also known as cancer stem cells), which constitute the minority of cells within the mass of a tumour? CD44 has been implicated as a CIC marker in several malignancies of haematopoietic and epithelial origin. Is this a fortuitous coincidence owing to the widespread expression of the molecule or is CD44 expression advantageous as it fulfils some of the special properties that are displayed by CICs, such as self-renewal, niche preparation, epithelial-mesenchymal transition and resistance to apoptosis?# S; J! P. f4 I# {& [4 U$ U
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原文链接：http://www.ncbi.nlm.nih.gov/pubm ... gov/pubmed/21390059（求原文）" U% c8 k( u5 S
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名词解释：壁龛：干细胞在机体组织中的居住环境
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* v2 e( Z6 c% i# H6 V请教达人们——CD44和肿瘤干细胞，有着怎样的联系？

deron

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2 j# ?% ^8 J8 K# ?4 h11年3月份的文章- z; E! d7 I4 e! {2 S
http://www.ncbi.nlm.nih.gov/pubmed/21390059

deron

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看来我明显级别不够。只能勉强看懂文章，无法完全理解意义