发一篇间充质干细胞的文献

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0 w3 k2 ~& L) {% w) y- D题目：Mesenchymal stem cells: clinical applications and biological characterization6 G3 @& k3 j2 A5 {# z7 f
摘要：Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum, trabecular bone, adipose tissue,! p! T. s. Q( ^8 k+ x8 h, P
synovium, skeletal muscle and deciduous teeth. These cells have the capacity to differentiate into cells of connective tissue
. Y0 V# L( I6 W; C' W* [3 B& [lineages, including bone, fat, cartilage and muscle. A great deal has been learned in recent years about the isolation and
8 {# A% P9 v7 U& ~. Ycharacterization of MSCs, and control of their differentiation. These cells have generated a great deal of interest because of
: z# w( k7 l! n1 ftheir potential use in regenerative medicine and tissue engineering and there are some dramatic examples, derived from both
: p/ `  n7 X8 \, ypre-clinical and clinical studies, that illustrate their therapeutic value. This review summarizes recent findings regarding the" R& h) s' Y) o& h- i" W9 G* r
potential clinical use of MSCs in cardiovascular, neural and orthopaedic applications. As newmethods are developed, there are
9 m5 k8 H  f" p$ n6 G5 }several aspects to the implanted cell–host interaction that need to be addressed before we can fully understand the underlying
) D! F9 ^2 i/ a7 B( U2 R9 amechanisms. These include the host immune response to implanted cells, the homing mechanisms that guide delivered cells5 R" _% a9 b- W$ N! \( d! z" Z
to a site of injury and the differentiation in vivo of implanted cells under the influence of local signals.