转贴：PNAS:科学家发现肿瘤干细胞的一种新来源

懵懂干细胞

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懵懂干细胞

我附上这篇文献的摘要！
- z- @5 E! L: b; a3 V% MCurrent  models  of  stem  cell  biology  assume  that  normal  and
2 D/ N+ Y, L5 zneoplastic  stem  cells  reside  at  the  apices  of  hierarchies  and  dif-
  y7 Y- k" ~! h; [. X) s9 o. i+ N3 gferentiate into nonstem progeny in a unidirectional manner. Here we& N! K7 E  o8 K/ {. C5 z
identify a subpopulation of basal-like human mammary epithelial
7 A, f( H% F0 J6 g7 B0 A0 Q& S  mcells  that  departs  from  that  assumption,  spontaneously  dediffer-5 R3 {5 \. h2 _" K
entiating into stem-like cells. Moreover, oncogenic transformation
4 @* _" q+ P0 venhances the spontaneous conversion, so that nonstem cancer cells: Z$ ]  Z  Y3 U. y$ p) c  F, b2 u
give rise to cancer stem cell (CSC)-like cells in vitro and in vivo. We
% Y5 w2 K# |* d* l7 U! L1 D- U0 G# ufurther show that the differentiation state of normal cells-of-origin is
$ I: j8 n3 P0 |$ na strong determinant of posttransformation behavior. These findings" Y7 Q7 J5 f: P) l- k! J3 T$ k
demonstrate that normal and CSC-like cells can arise de novo from
7 r0 w$ F3 i5 f& jmore differentiated cell types and that hierarchical models of mam-
' Y8 m3 v; q: W4 z) L3 m4 Rmary stem cell biology should encompass bidirectional interconver-
9 w# f( T* s/ ?4 j" N1 psions  between  stem  and  nonstem  compartments.  The  observed" a9 k- g0 h  O0 s% S  r3 S1 T0 t0 b
plasticity may allow derivation of patient-specific adult stem cells- ]1 V6 K! Z" z1 ~( {( x. E5 J1 }/ U
without genetic manipulation and holds important implications for
( l, Z7 H* f! b6 C2 P' Ktherapeutic strategies to eradicate cancer.' x3 S- M1 W0 \: H" A! _3 ]+ V
个人认为，肿瘤细胞自发转化成“干性”细胞是有可能的，甚至有可能形成iPS细胞呢，这其中最主要的影响因素就是转化概率，% [( @- h5 u. l% Y+ M) U1 ~6 P
有可能形成了，当在众多肿瘤细胞小群体中有可能存活不了，所以它的存在有可能是比较短的某个时间段才能被察觉到的，所以该文献能发在PNAS上是因为察觉到了这难以察觉的，只能发PNAS应该是因为该实验重复性不高！再说目前“干性”肿瘤细胞的标记也不是很清楚！