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Expert Opin Ther Targets. 2010 Oct;14(10):1109-20.$ x! Z) J% g! u2 ]8 R6 U2 s
Targeting miRNAs in osteoblast differentiation and bone formation.
3 i" R( Z! L; x, d/ z2 w2 tHu R, Li H, Liu W, Yang L, Tan YF, Luo XH.* D$ m9 y1 S. [ H T8 X
SourceThe Second Xiangya Hospital of Central South University, Institute of Endocrinology & Metabolism, Changsha, Hunan 410011, PR China." z% n/ H1 s. e9 ^) s
* c. h. e1 W* F$ M9 ~Abstract* P2 P0 m0 ]" g7 y/ X6 E
IMPORTANCE OF THE FIELD: Bone tissue arises from mesenchymal stromal cells (MSCs) differentiated into the osteoblast lineage by genetic and epigenetic mechanisms. Emerging evidence indicates that the class of small non-coding single-stranded RNAs known as "microRNAs (miRNAs)" also plays a critical role in this process., C0 S; {2 o8 p
$ F: q4 u9 e* s+ bAREAS COVERED IN THIS REVIEW: In this short review, we summarize the biology and functional mechanisms of miRNAs. Importantly, we discuss miRNA expression, miRNA function, miRNA target prediction, miRNA overexpression and inhibition methods applied in osteoblastogenesis.6 Y$ S7 S* q+ V7 C4 w4 c7 P4 p
, b! b+ X4 E0 S& N$ eWHAT THE READER WILL GAIN: We discuss the potential therapeutic opportunities and challenges for improving the treatment of bone-related diseases by using miRNAs as a therapeutic target., q X, |8 f0 U8 g
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TAKE HOME MESSAGE: Although various microRNAs regulate cell proliferation and differentiation, only a few miRNAs has been reported so far to play a key role in the regulation of osteoblast differentiation and bone formation.* j/ }2 f9 J+ h. x" ]
/ w& V% U/ L% v, L1 \) nPMID: 20690886 [PubMed - indexed for MEDLINE] |
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