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4、transgenic mouse models have shown that mutant Hras targeted to the hair follicle region highly predisposed mice to squamous carcinomas, whereas its targeting to more differentiated interfollicular or suprabasal cells resulted in papillomas with low malignant potential。Moreover, transformation of distinct breast epithelial cells in vitro has indicated that the target cell is an important determinant of tumour phenotype; ) S$ n: q" l: g3 z$ X O, i
转基因小鼠模型显示,毛囊区域Hras的突变会诱发小鼠产生鳞状细胞癌的趋势,反之针对更多已分化的毛囊内或基底层以上细胞将导致低恶性潜能的乳头状瘤。此外,不同的乳腺上皮细胞体外转化表明靶细胞具有一个肿瘤表型的关键特征;
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