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Emerging models and paradigms for stem cell ageing ) e! y6 s6 x& j+ j: [
D. Leanne Jones and Thomas A. Rando
8 n* S0 ?% r# {6 aAgeing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair.
8 @% q U( U4 @Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction! V( M* w1 Y+ Y$ [) b
in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal& z$ X/ u, W. _7 j
and aberrant differentiation potential.
. p6 x' o# k2 Y! i. q$ f"Nature cell biology 13(5) 2011"
9 I1 n4 i4 x% j$ l! ^ |
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发表于 2011-7-11 10:26
