谈谈tet和5-hmC

hongjie88

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我看最近有好多关于这个的文章啊，貌似是很火
6 S* U( K; F! }3 L" N列几个跟大家分享一下
5 @: N! f* c$ J1 Y- jTet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.Cell Stem Cell. 2011 Aug 5; 9(2): 166-75! K8 @5 w# [6 m
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.Cell Res. 2011 Jul 123 ]- _* b$ ~; Z6 P
Tissue specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genome.J Biol Chem. 2011 May 24, G1 a! ~, t; R; O
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.Nature. 2011 May 8;
  D; C" e, q" f- Y- j& WGenome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells.Mol Cell. 2011 Apr 20; 1 I+ u6 T# W* J
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.Nature. 2011 Apr 3; 7 `! w/ }8 _- v' H% F
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Genes Dev. 2011 Apr 1; 25(7): 679-84
. b0 v- X7 V  q0 k. @+ K& qDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.Nature. 2011 Mar 30;
2 ?- t( M8 J5 U2 R. FTet1 and tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.Cell Stem Cell. 2011 Feb 4; 8(2): 200-13
5 q5 \- R6 B" Y% f4 o) e2 R这才半年就有这么多文章。。。
# ^5 [" d6 O( W8 Z3 i. ]大家感兴趣的交流一下吧
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hongjie88

回复 hongjie88 的帖子
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我这有全文的只有几篇，大家继续补充啊~~

kephort

这是一个很好的话题啊，动物细胞DNA的去甲基化问题不甚别了，貌似现在开始逐渐浮出水面了。5 f4 k3 C0 E% o* N' s2 ]' F/ Z* B
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Tet到底与DNA去甲基化之间有什么关系？在DNA去甲基化过程中如何起到调控作用？目前文献中采用了哪些方法能说明5-hmc是/否为去甲基化的中间状态？欢迎看了这方面的达人列一下啊？) i' n, r$ ]* l4 s. p" i/ e
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另外：从方法学上，除了抗5-hmc的抗体可以分析5-hmc外，还有哪些文献报道了相关的分析方法？欢迎大家汇总。

fwyou

好像缺几篇文献吧
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Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.Cell Stem Cell. 2011 Aug 5; 9(2): 166-75
% H0 S2 [0 I' N! V9 i" p( ^3 |6 PGenome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells.Mol Cell. 2011 Apr 20;
4 ^6 c% j! v$ c' v3 {/ WGenome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Genes Dev. 2011 Apr 1; 25(7): 679-84; W; |: v3 `! N3 R* D! M- B! W6 U
都没有啊
$ q" c$ {9 T: U版主，你有没？
3 [. @. s  z4 ~或者群友别人有没》？

yeya

我来上传吧。貌似生化所最近SCIENCE也有发Tet

xlwhzp

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science上最新的两篇文章及supplementary material) b, y* ?4 x. Z7 U( p( X5 g3 J5 A
cell stem cell 上有最新的一篇文章关于干细胞和5hmC的，链接是http://www.sciencedirect.com/science/article/pii/S1934590911003407，

游侠儿2012GX

我这里也有几篇，供大家参考
- q4 ?% I( d3 U/ MTET Genes: new players in DNA demethylation and important determinants for stemness, Experimental Hematology 2011;39:272–281
5 E% r- |1 I/ H9 l0 eTET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity,1 9 M AY 2 0 1 1 | VO L 4 7 3 | N AT U R E | 3 4 3; B3 a2 e8 P5 `$ z2 m
Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine
, E; B4 ?' g; Y) m7 LThe role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

游侠儿2012GX

我在一篇文章里面看到Ayu17-449, a novel gene on mouse chromosome 3, was identified by the gene trapping technique previously reported by Tang et al. (2006). In NCBI database analysis, Ayu17-449 is also called TET-2 (tet oncogene family member 2). It belongs to a novel, well-conserved, protein family but with unclear biological function, the TET protein family, including three members (TET-1, TET-2 and TET-3). 不知道这tet2是不是Ayu17-449