人间充质干细胞调节同种异源免疫细胞应答

naturalkillerce

回复 deron 的帖子# a2 n1 z+ @  V0 J

$ A1 h8 z9 v* x- z“Transplanted allogeneic MSCs can be detected in recipients at extended time points”可尝试翻译为“在延伸的时间点上，能够在受体内检测到移植的同种异源MSC”

naturalkillerce

by coculturing them with purified subpopulations of immune cells，即通过将人MSC与纯化的免疫细胞亚群共培养。7 V0 G  N/ K. \1 Q5 h2 Z
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hMSCs altered the cytokine secretion profile of dendritic cells (DCs), naive and effector T cells (T helper 1 [T(H)1] and T(H)2), and natural killer (NK) cells to induce a more anti-inflammatory or tolerant phenotype.即hMSCs改变了树突状细胞、初始T细胞(naive T cells)、效应T细胞和自然杀伤细胞的细胞因子分泌谱，从而诱导产生一个更加抗炎性或耐受性的表型。