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”he trial is designed to establish safety of the cells. One worry of the FDA and the scientific community is that HESC will produce teratomas (a stem cell tumor).5 {6 H0 z% I9 G& f! `6 W
Geron played it very safe. They differentiated these cells so that they produce only oligodendroglial cells and are very unlikely to produce teratomas. They chose to transplant the cells into patients with thoracic complete spinal cord injuries so that if the cells turned into tumors, the neurological consequences will be minimized.“- t1 Y. k2 P/ _" x2 t, x
所以临床实验最终会shut down也是很有可能的,Geron他们自己当初并不是不清楚这点。可能到现在这个地步,实在找不到其他办法继续了。我并不担心这样的临床会终止,就像上面说的“杰青”迟早会出现。私心的说,真希望能是在中国。 |
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