HOXD 与 digits 发育的关系

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" \) I' i1 x& `2 E( [0 E2 E* t7 i上课做的作业
2 R. I  A% U; q0 G: w; I% ~A Regulatory Archipelago Controls Hox Genes Transcription in Digits
: b6 P2 C$ p$ c* r+ @8 d- X6 VSUMMARY- p* _+ y, S. o" f
The evolution of digits was an essential step in the; W) M) a6 T# y6 B9 ]; x* h% a! {
success of tetrapods. Among the key players, Hoxd
- M, R+ y+ l% ?* O8 @. z7 W, s' dgenes are coordinately regulated in developing
$ ^6 R# _9 I+ D$ K1 e0 V9 |digits,where they help organize growth and patterns.
% W7 e8 f/ _. F3 r" V8 L: ^We identi旻搀 the distal regulatory sites associated
% a2 i6 m( D3 \7 E) ]* Jwith these genes by probing the three-dimensional
* V1 B0 ?- U6 l0 `) P* _0 Farchitecture of this regulatory unit in developing, A* M8 ~* @- ~6 v6 w
limbs. This approach, combined with in vivo dele-9 f6 M+ E  |4 _/ X3 c) K
tions of distinct regulatory regions, revealed that: a8 w* z/ _. R7 \
the active part of the gene cluster contacts several4 S5 e% z% ]' ?  h- e
enhancer-like sequences. These elements are4 \$ a5 o5 t# x: \5 I8 ~7 f2 K
dispersed throughout the nearby gene desert, and
9 O( v7 \  S& P0 Oeach contributes either quantitatively or qualitatively- y% l! O0 I: q0 p1 \# h) M/ ^
to Hox gene transcription in presumptive digits. We
8 y) U* r* d# Z4 g6 F$ a( upropose that this genetic system, which we call
& z4 I. P9 k/ ~% {. s6 z5 Oa ‘‘regulatory archipelago,’’ provides an inherent 旻砀-' ]& D/ n/ o& }5 \
ibility that may partly underlie the diversity in number& `& v0 k' I! a' E9 X9 ]& D
and morphology of digits across tetrapods, as well
9 I% g2 {0 s0 {' o& d7 D. Zas their resilience to drastic variations.
  H% Y: p  O# s' [: e, s蛮有意思的一个paper，让我了解了为啥大家的爪子长的都不太一样。