cell+ Origin of New Glial Cells in Intac and Injured Adult Spinal Cord

suning5

everal distinct cell types in the adult central nervous
4 c( A( c1 R* psystem have been suggested to act as stem or prog-
5 P9 i! s: n8 T9 t, Tenitor cells generating new cells under physiological
8 _: r. v8 k( Ior pathological conditions. We have assessed the9 K7 i/ l$ j/ X
origin of new cells in the adult mouse spinal cord by2 h  I- j3 l% m1 O' P2 ^
genetic fate mapping. Oligodendrocyte progenitors
0 |( q8 o8 z9 l5 h1 c1 w' N) e; Mself-renew, give rise to newmature oligodendrocytes,
* Q4 E' i; T6 i( l% `8 Rand constitute the dominating proliferating cell popu-+ t! J# M: U( R/ n
lation in the intact adult spinal cord. In contrast, astro-
: ~: s1 E" i3 O; j2 C7 G2 P5 kcytes and ependymal cells, which are restricted to5 ^. X) r2 p" P2 M5 G
limited self-duplication in the intact spinal cord,0 {4 e" ~7 E+ L/ b/ b: ?: ?
generate the largest number of cells after spinal cord" `$ A& |( m" Y3 ]# ^+ Y
injury. Only ependymal cells generate progeny of4 j+ s7 Y3 j% s1 E8 e! ^
multiple fates, and neural stemcell activity in the intact' }4 M7 X* J& h1 j- T
and injured adult spinal cord is confined to this cell, {% z% M, h* ?: R. E5 n- T7 q4 m4 e
population. We provide an integrated view of how# H' B6 ?: y- r0 T3 g
severaldistinct cell types contribute in complementary
7 `2 o' \. c) P+ mways to cell maintenance and the reaction to injury.

杏花

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舒思

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awen

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陈晴

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罗马星空

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tempo

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xuguofeng

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123456zsz

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txxxtyq

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