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本帖最后由 jiays 于 2012-2-5 21:40 编辑
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Nat Rev Mol Cell Biol. 2011 Jun;12(6):344-5. doi: 10.1038/nrm3116. Epub 2011 Apr 29.0 g5 C7 A& h3 F2 j$ d B" f, g
Autophagy: shaping the fate of mitochondria.
. j. e! Z' n8 Z4 e9 uWrighton KH., t- A$ l" T1 h
Comment on
) o1 Y/ o7 B6 XNat Cell Biol. 2011 May;13(5):589-98.
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' \& X0 ?$ p7 T7 {+ H; |* o. zNat Cell Biol. 2011 May;13(5):521-2." Z, s9 Q& g7 y8 D4 v1 D$ p$ `
Mitochondria unite to survive.
" `+ U/ g, ^! t: vBlackstone C, Chang CR.+ S$ S" e& N: g, \% T9 n
Abstract
* r1 c- r8 }/ I5 W+ hStarvation of animals or cells triggers autophagic degradation of cell contents to retrieve nutrients, but, paradoxically, mitochondria enlarge. This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1. Elongation of mitochondria optimizes ATP production and spares them from autophagy-mediated destruction./ n0 N" ~$ u8 C9 D& ]7 k) t
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Comment on7 a5 R! D, @) O" v2 f; T, F# ~
Nat Cell Biol. 2011 May;13(5):589-98. 6 Z+ z) E7 P# q0 d; g
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发表于 2012-2-5 21:39
