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本帖最后由 细胞海洋 于 2012-2-17 00:44 编辑 $ N( Y. ^8 D6 C5 x% Y3 v
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e channelrhodopsins are light-gated ion channels, found in algae, that have rapidly become familiar in the neuroscience lab as optogenetics reagents: the activities of neurons expressing channelrhodopsins can be optically controlled within systems as complicated as living mammals. The X-ray crystal structure of a chimaera of two channelrhodopsins has now been determined at 2.3 Å resolution. The structure reveals the molecular architecture of this ion channel, including the retinal-binding pocket and cation conduction pathway. This work paves the way for the design of new channelrhodopsin variants with enhanced properties. Cover image: Hiroshi M. Sasaki. |
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发表于 2012-2-16 23:26
发表于 2012-2-17 14:11
