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On page 829, Watson et al. find that the small GTP-binding protein TC10 must be in a lipid raft compartment to impact insulin signaling. Such spatial control may be one way in which cells create a distinct reponse from activation of a common set of signal transduction proteins.
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Insulin acts on the insulin receptor to trigger translocation of the GLUT4 transporter to the plasma membrane, resulting in increased glucose uptake. In previous studies, activation of both PI 3-kinase and TC10 were implicated in transducing a signal from activated receptor to GLUT4.
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Now Watson et al. show that TC10 localizes to lipid raft domains, and that inhibition of this localization (using a dominant-interfering caveolin mutant) prevents TC10 activation by insulin. Although the current authors and others have worked out a complex series of links from the activated receptor to TC10, it seems that these links can only be set up productively when the relevant proteins are concentrated in a specific domain.(TC10 (green) colocalizes with caveolin () |
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发表于 2009-3-5 23:40
发表于 2015-6-3 10:43
