干细胞之家 - 中国干细胞行业门户第一站

 

 

搜索
朗日生物

免疫细胞治疗专区

欢迎关注干细胞微信公众号

  
查看: 626652|回复: 251
go

The leg bone's connected to the...cerebellum [复制链接]

Rank: 7Rank: 7Rank: 7

积分
威望
0  
包包
3465  
楼主
发表于 2009-3-5 23:46 |只看该作者 |正序浏览 |打印
In a result that bodes well for medical applications of stem cells, Priller et al. report on page 733 that bonemarrow-derived stem cells can differentiate into apparently normal Purkinje neurons in an adult mouse brain. Although previous work demonstrated that bone marrow transferred into an irradiated mouse could give rise to cells expressing neuronal markers, the authors are the first to identify donor-derived neurons that appear to be morphologically normal and functional, and to determine that the donor-derived cells survive as the mouse ages.
$ a& o) _8 g$ I7 `5 V! I0 S* d9 B; [- x8 i; W' l& ?) z% m0 G
The authors transferred the green fluorescent protein (GFP) gene into donor bone marrow cells, and then identified GFP- expressing cells in the brains of mice that received the transplanted bone marrow. Donor-derived Purkinje cells were not seen four months after transplantation, but had appeared by 12 months posttransplantation and persisted at least three months beyond that, observations that encompassed most of the lifespan of the mice. Priller et al. speculate that the delayed colonization of the cerebellum by the donor cells may be due to the death of the recipient's original Purkinje cells during aging. If true, this model suggests that bone marrow-derived stem cells might be able to preferentially regenerate neurons lost to aging or disease.(A bone marrow cell (yellow) can develop )

Rank: 2

积分
71 
威望
71  
包包
1850  
252
发表于 3 天前 |只看该作者
很好!很强大!  

Rank: 2

积分
82 
威望
82  
包包
1674  
251
发表于 2025-5-16 19:52 |只看该作者
帮顶  

Rank: 2

积分
107 
威望
107  
包包
1654  
250
发表于 2025-5-14 19:54 |只看该作者
干细胞之家微信公众号
呵呵 那就好好玩吧~~~~  

Rank: 2

积分
123 
威望
123  
包包
1650  
249
发表于 2025-5-3 16:27 |只看该作者
回复一下  

Rank: 2

积分
64 
威望
64  
包包
1734  
248
发表于 2025-3-30 03:42 |只看该作者
不错,看看。  

Rank: 2

积分
89 
威望
89  
包包
1671  
247
发表于 2025-3-10 04:15 |只看该作者
都是那么过来的  

Rank: 2

积分
159 
威望
159  
包包
1670  
246
发表于 2025-2-15 16:45 |只看该作者
表观遗传学

Rank: 2

积分
63 
威望
63  
包包
1699  
245
发表于 2025-1-16 00:24 |只看该作者
说的真有道理啊!

Rank: 2

积分
97 
威望
97  
包包
1659  
244
发表于 2025-1-9 14:13 |只看该作者
谢谢分享了!  
‹ 上一主题|下一主题
你需要登录后才可以回帖 登录 | 注册
验证问答 换一个

Archiver|干细胞之家 ( 吉ICP备2021004615号-3 )

GMT+8, 2025-5-29 05:48

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.