胎盘中造血干细胞的量

death0270

其实通过查文献，确实可以发现不少文献表明胎盘中的造血干细胞确实多过脐带血中，问题在于提取过程过于复杂，并且提取物会富含杂质，并没有一个能够提纯同时成本低廉的方法来纯化提取物。至于说文献出处，确实很多，我只举例一篇
7 [) n4 P) f3 O; Q$ jExperimental Biology and Medicine 234:813-823 (2009)doi: 10.3181/0809-BC-2626 n& Q8 t" D3 @3 f
Human Term Placenta as a Source of Hematopoietic Cells; S/ w5 M/ c5 Y2 ?( Q
Vladimir Serikov, Catherine Hounshell, Sandra Larkin, William Green, Hirokazu Ikeda, Mark C. Walters and Frans A. Kuypers1
  \) W" D, E, {" l1 Children’s Hospital Oakland Research Institute, Oakland, California 94609+ s5 w, ?1 A# Q: S! M- ~, s2 B
The main barrier to a broader clinical application of umbilical cord blood (UCB) transplantation is its limiting cellular content.   M  f& Z% t, o2 `& n1 _2 Y* e7 W
Thus, the discovery of hematopoietic progenitor cells in murine placental tissue led us investigate whether the human placenta ! w0 l( d( v, [! A
contains hematopoietic cells, sites of hematopoiesis, and to develop a procedure of processing and storing placental hematopoietic
2 c: F" K) l+ }! z5 D  Icells for transplantation. Here we show that the human placenta contains large numbers of CD34-expressing hematopoietic cells, with the potential to provide a cellular yield several-fold greater than that of a typical UCB harvest. Cells from fresh or cryopreserved placental tissue generated erythroid and myeloid 0 K* j7 _. L6 J2 l% R4 T
colonies in culture, and also produced lymphoid cells after transplantation in immunodeficient mice. These results suggest that human 5 v+ \+ @$ P% U, g9 i3 I" N, S
placenta could become an important new source of hematopoietic cells for allogeneic transplantation.