《细胞》[Cell]12年7月6日出版pdf全文

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) s) O* l  ]  COn the cover: Sculpting a functional mRNA out of a pre-mRNA transcript involves coordination of multiple processing events, including pre-mRNA splicing and 3′ cleavage and polyadenylation. Previous work showed that components of these processes were interlinked because U1 snRNP that is crucial for splicing also functions to protect mRNAs from aberrant cleavage and polyadenylation at cryptic polydenylation signals (PASs). In this issue, Berg et al. (pp. 53–64) show that U1 snRNP (U1) plays a key role in suppressing PAS usage throughout pre-mRNAs and that these interactions may serve regulatory functions. The cover image depicts legions of U1 “defenders” protecting the nascent pre-mRNA (green) from the constant threat of cleavage and polyadenylation hordes riding on the tail of RNA pol II. Conceptual design by Gideon Dreyfuss. Artwork by Lili Guo, Chonghui Ma, and Zhaoming Guo.- R5 J7 a, B5 e7 K0 B

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