干细胞之家 - 中国干细胞行业门户第一站

 

 

搜索
朗日生物

免疫细胞治疗专区

欢迎关注干细胞微信公众号

  
查看: 636620|回复: 264
go

Home | Help | Feedback | Subscriptions | Archive | Search | Table of C [复制链接]

Rank: 7Rank: 7Rank: 7

积分
威望
0  
包包
3465  
楼主
发表于 2009-3-6 00:23 |只看该作者 |正序浏览 |打印
This Article
, u3 a/ l% O2 l$ \; B% S( M! n" w- r$ F1 G% w
PDF (Full Text)
( A- O# _# {( _# `! h2 U# u; H% S7 ^3 K
Alert me when this article is cited
( K6 r; }2 y8 O/ I4 U
7 U: P2 w0 [6 G" P  S) S" K6 RServices' a1 f1 D- E$ S' {, L, }

7 ^" j/ o+ U, R: m. f# _5 tAlert me to new content in the JCB& n0 \, H3 X2 i
) ~: ^  }5 j* R9 ^
Download to citation manager% r4 T3 P9 U2 ~1 o

, Q% {4 P  v% K( H0 eGoogle Scholar, I. P6 N0 N* r' l0 n% t8 [
5 K) y' D4 j  d/ C8 m7 t
Articles by LeBrasseur, N.$ E# [1 \6 j" f2 ^

; Z0 i4 N' G, ]6 u% i: RArticles citing this Article" B$ I* R3 a. G8 ]6 O# d8 D

0 S/ S, _. ?% w3 T+ ^1 d+ ]) FPubMed
0 X$ G" H' y2 Z5 K, h
3 a  ]  A+ A. x. NArticles by LeBrasseur, N.
1 ~! z' }  \6 |( Q: W  [
) h7 I! m/ y& V* l? The Rockefeller University Press, 0021-9525/2002/9/1154-a $5.001 L: {& E; L6 _5 ^
: _* J! S# o8 o+ P% N$ G
The Journal of Cell Biology, Volume 158, Number 7, September 30, 2002 1154-a-1154/ ?* U: V7 K- C
% O% a+ ]7 z. m
Research Roundup
! B  R1 v* @% c- N# P7 k8 Y) t' W1 R
Semaphorins〞not just for axons
/ Q+ T; B4 C6 C: f/ B( t5 Y/ i( z
! @1 `2 d* F/ t1 a5 {Semaphorins (middle) and SF (bottom) both induce invasive growth.$ ]% y5 L1 w) t; A  x
( y, w) F' n) _+ h. y# z& S$ K% R
Comoglio/Macmillan
7 `( w+ k8 K+ {* P  ^
) ^  S7 E( t: a' A$ V( o7 EAn axon guidance factor can work with growth factor receptors to trigger invasive growth, according to a recent article by Silvia Giordano, Paolo Comoglio, and colleagues (Institute for Cancer Research, University of Torino, Torino, Italy).  r1 Z0 r+ Q: K0 V2 S9 g
7 B# c: k  a* E
The guidance cues are semaphorins, soluble and cell surface molecules that have homology to Met, a scatter factor (SF) receptor tyrosine kinase. Met and semaphorins also share homology with the extracellular domain of semaphorin receptors, known as plexins. Because plexins and semaphorins are expressed outside the nervous system, Giordano et al. examined what function they might control in other tissues." n9 E8 `  G2 e
3 n; }" W9 L. K1 [1 l& a2 |
They found that ligand stimulation of a plexin in epithelial cells caused invasive growth, including scattering and anchorage-independent growth. Met is the only kinase known to trigger invasive growth and, as expected, without Met, this plexin-stimulated growth was blocked. Epithelial cells seem primed for crosstalk between the two receptors, as Met and plexin were in a preformed complex, mediated by their conserved domains. SF and semaphorins in combination produced a stronger response than either alone. "These two modalities of activation can cooperate for certain biological responses but not for others, and this could be a way to fine tune responses such as invasion, without interfering with growth," says Giordano.
9 T' X! h- r7 D1 M( O3 y) u9 c* M% ?' d$ U+ B- D8 m3 V2 F
Reference:
, [4 G9 h$ T, }9 ?" [
4 n" N/ I2 G" i" W- X6 yGiordano, S., et al. 2002. Nat. Cell Biol. 4:720–724.(Published online 23 September)

Rank: 2

积分
51 
威望
51  
包包
1711  
265
发表于 前天 23:27 |只看该作者
楼主福如东海,万寿无疆!  

Rank: 2

积分
159 
威望
159  
包包
1670  
264
发表于 2025-5-5 06:03 |只看该作者
哈哈,看的人少,回一下  

Rank: 2

积分
106 
威望
106  
包包
1553  
263
发表于 2025-2-19 18:59 |只看该作者
干细胞之家微信公众号
我在努力中  

Rank: 2

积分
72 
威望
72  
包包
1730  
262
发表于 2025-2-15 00:55 |只看该作者
真是天底下好事多多  

Rank: 2

积分
126 
威望
126  
包包
1748  
261
发表于 2025-2-4 07:01 |只看该作者
支持一下吧  

Rank: 2

积分
126 
威望
126  
包包
1748  
260
发表于 2024-10-29 10:28 |只看该作者
好人一个  

Rank: 2

积分
171 
威望
171  
包包
1765  
259
发表于 2024-8-10 13:15 |只看该作者
干细胞抗衰老  

Rank: 2

积分
61 
威望
61  
包包
1757  
258
发表于 2024-8-2 13:09 |只看该作者
几头雾水…  

Rank: 2

积分
66 
威望
66  
包包
1714  
257
发表于 2024-7-24 08:39 |只看该作者
干细胞研究重在基础
‹ 上一主题|下一主题
你需要登录后才可以回帖 登录 | 注册
验证问答 换一个

Archiver|干细胞之家 ( 吉ICP备2021004615号-3 )

GMT+8, 2025-5-30 02:19

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.