《自然》[Nature]12年12月13日出版pdf全文

nero1981

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At the end of cell division in animal cells, the mother cell splits into two daughter cells and partitions segregated chromosomes in a process called cytokinesis. The mitotic spindle controls cytokinetic events at the plasma membrane, but the mechanisms connecting these two macrostructures have been unclear. Mark Petronczki and colleagues now present a structural and functional analysis that identifies centralspindlin, a protein complex in the spindle midzone and midbody, as a missing link between the mitotic spindle and the plasma membrane — a link that secures the final cut during cytokinesis. The authors identify a domain in the MgcRacGAP subunit of centralspindlin as a tether that binds to phosphoinositide lipids in the plasma membrane. On the cover, a fluorescent light micrograph of a cell in the metaphase stage of mitosis. (Torsten Wittmann/Science Photo Library). A5 `2 x: `( m4 S2 z
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