PDF电子书：Stem Cell Engineering Principles and Applications 2011

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Book Title
/ y6 V$ z, h  @6 Z* z5 Y# r( ^! FStem Cell Engineering
3 G" D  k; X; L3 r4 QBook Subtitle! W- E4 T' C2 t7 H
Principles and Applications
3 W: m7 G2 V( YCopyright% b" b4 c- C2 c! ^/ f  H# T( b
2011  D3 b" }% v2 ?; ^2 B
DOI" h# F2 k% N4 s! b' g# q0 f
10.1007/978-3-642-11865-4
2 {! u+ N" H! j+ ePrint ISBN
  b5 y: a+ C4 M) [5 o& N978-3-642-11864-7$ x  d8 y8 ~  m/ q& _: w
Online ISBN6 ^! ]/ k% Y. I" S  ]
978-3-642-11865-4
, Q, }; L+ h( Q0 NPublisher
  k; P. b% E+ S( J1 k$ nSpringer Berlin Heidelberg
; `& U$ P/ w$ `# \/ }1 ~" WCopyright Holder
3 Z: `& i+ b" w& lSpringer-Verlag Berlin Heidelberg
( H( V- [# b5 P; j, p$ x* z8 i; h; I; K5 x( N( E! d
- Reviews Engineering Approaches in Stem Cell Research
3 a+ _9 }9 T0 N. Q0 P: v& n# i- Provides a solid reference for researchers and advanced graduate student- `2 }/ [$ m6 A" W9 I6 R0 g
The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.
" l  h$ ?8 O4 u2 [# cContent Level » Research
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3 E( ?' S+ R8 J: H# r8 {Keywords » bioreactors - cell expansion - differentiation - drug discovery - embryonic stem cell growth - stem cell growth
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8 E! _1 ^  F5 v& e4 O( \- X" aRelated subjects » Biomedical Engineering - Biotechnology - Cell Biology8 R9 L, T  T9 D& Y
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Contents
% F* R# @3 M9 J% B8 a- dPart I Instead of an Introduction – The Emperor’s New Legs
, Q8 z* W% m. o' lThe Emperor’s New Body: Seeking for a Blueprint of Limb7 s7 y9 \2 ]2 K8 _8 u
Regeneration in Humans . . . . . . . . . . . . . . . . . . . . . . . . . . 3! q9 F1 u- y3 j" D8 ]
Ilya Digel and Aysegül Temiz Artmann
% ~3 J* d8 D4 `+ a) dPart II Basics and Basic Research
( K3 v8 H; M) I# e% w  Z* hEngineering the Stem Cell Niche and the Differentiative Microand
# R3 _$ }! y: E. u( sMacroenvironment: Technologies and Tools for Applying
/ V! r- ^0 i/ f, }8 G$ y$ xBiochemical, Physical and Structural Stimuli and Their Effects
0 F5 L8 B( q* l; Von Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
+ g( w& b4 T$ V( w" A+ X& F1 u. s( KPaolo Di Nardo, Marilena Minieri, and Arti Ahluwalia( C" r5 J( f. \% V/ O) G
Differentiation Potential of Adult Human Mesenchymal Stem Cells . . 61) Y$ N) u5 Q1 G5 U- G& ~( v
Edda Tobiasch: |+ h$ t  ~( b0 f! m  S
The Potential of Selectively Cultured Adult Stem Cells% M- `4 G8 k8 N" [, V/ I9 k+ S2 d1 x) G
Re-implanted in Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . 79. u) ~5 \& i1 C7 |( W
Isgard S. Hueck, Martin Haas, Rita Finones, Jane Frimodig,
) U& c- ~9 _( Q) J5 o7 Z- nand David A. Gough
0 \1 G/ I7 ~2 V* f9 x& l1 mEnhanced Cardiac Differentiation of Mouse Embryonic Stem
5 Q) _! s6 E& w5 }* BCells by Electrical Stimulation . . . . . . . . . . . . . . . . . . . . . . . 119
6 P' p3 k/ r) Y  vPaul R. Bidez III, J. Yasha Kresh, Yen Wei, and Peter I. Lelkes9 r, t0 ~. h  F6 T' m
The Therapeutic Potential of ES-Derived Haematopoietic Cells . . . . . 143. M& b2 c5 P/ a
Sabrina Gordon-Keylock and Lesley Forrester# O4 Q, Z, E. K* n: E7 S
Genetic Modification of Human Embryonic and Induced6 E1 h$ a: {1 E7 g' g- ~
Pluripotent Stem Cells: Viral and Non-viral Approaches . . . . . . . . . 1594 A$ S0 R$ ]2 j; K: u
Nicole M. Kane, Chris Denning, and Andrew H. Baker
8 n4 o7 B. M, e8 rThe Immune Barriers of Cell Therapy with Allogenic Stem2 a9 ?! G$ }% ^4 Y8 I4 V
Cells of Embryonic Origin . . . . . . . . . . . . . . . . . . . . . . . . . 181* Z( w  u% E1 B. b6 C7 P
Olivier Preynat-Seauve, Karl-Heinz Krause, and Jean Villard" B% u, W( v* F2 q1 {# _- T0 Y
xxxi* F9 K1 u% X4 _% h( f7 ]
xxxii Contents4 g0 Y: z7 f4 h9 p" d
Reponses of Mesenchymal Stem Cells to Varying Oxygen) z! U# J- t% ]2 y3 g; v
Availability In Vitro and In Vivo . . . . . . . . . . . . . . . . . . . . . . 199
4 l. J, ^/ t# w8 y6 Q; t7 e1 `Frank R. Kloss, Sarvpreet Singh, and Günter Lepperdinger
; Q4 \. [0 r" g) A/ @7 SEndothelial Progenitor Cells and Nitric Oxide: Matching* g8 x0 H! u9 x; n; ?
Partners in Biomedicine . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
* n' ^0 P2 s& y. A- h- a+ MStefanie Keymel, Burcin Özüyaman, Marijke Grau, Malte Kelm,
6 X" k9 [+ X  |, k& r) d1 Oand Petra Kleinbongard
7 n+ C, X/ k1 N+ {& Y$ R, sSkeletal Stem Cells and Controlled Nanotopography . . . . . . . . . . . 247
* Q9 i0 i: }; k& W" H& lMatthew J. Dalby and Richard O.C. Oreffo+ H, o7 q$ Q: `% F
Part III Clinical Applications
5 k- Y7 R6 l: c; @  SCells and Vascular Tissue Engineering . . . . . . . . . . . . . . . . . . . 261
( Z, B* m% \0 {, }4 DJohn Paul Kirton, Tsung-Neng Tsai, and Qingbo Xu. A' a6 J$ I1 a$ _: S, D* f
Endothelial Progenitor Cells for Vascular Repair . . . . . . . . . . . . . 297) @. H) t& B- u" F* B* F( G
Melissa A. Brown, Cindy S. Cheng, and George A. Truskey* C% q+ l" I$ `' z0 |
Regenerating Tubules for Kidney Repair . . . . . . . . . . . . . . . . . 321) m  b) k1 c5 Z4 B# z' N1 z
W.W. Minuth, L. Denk, and A. Roessger
" \3 k8 V7 d! U& EStem Cells in Tissue Engineering and Cell Therapies
* j' Q* ^3 f$ J1 R2 A" w' Sof Urological Defects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345( o+ x: M( F$ H
Christoph Becker, Katrin Montzka, and Gerhard Jakse& b) a9 R  a; P
Bio-synthetic Encapsulation Systems for Organ Engineering:5 w& z6 C- \, X4 ]3 W. j3 X2 D* c# r( X
Focus on Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3631 C2 L7 p* g/ c: n
Rylie A. Green, Penny J. Martens, Robert Nordon,- q0 z* O0 U: `) K
and Laura A. Poole-Warren' Z! K; N' g  h# w: y) `7 D
Stem Cell Engineering for Regeneration of Bone Tissue . . . . . . . . . 3832 l! p) R, _% r9 z
Michael Gelinsky, Anja Lode, Anne Bernhardt, and7 S" ?( U0 Z; w$ O& A
Angela Rösen-Wolff1 H4 p+ j8 J3 |! b! T) n0 L8 B5 o
Part IV Techniques and Applications# p1 N& z/ V/ ]1 B3 `3 X8 L" j
Building, Preserving, and Applying Extracellular Culture
2 ^+ M: Y, J) M+ K& C( UIntegrity Using New Cell Culture Methods and Surfaces . . . . . . . . . 403& j( L3 ^! r+ i7 y8 d8 P
Thomas Brevig, Robin Wesselschmidt, and Masayuki Yamato/ I. |9 K3 f  }2 H5 G8 @$ l
Fabrication of Modified Extracellular Matrix
3 e* V0 [/ F# w6 ]' m- Afor the Bone Marrow-Derived Mesenchymal Stem Cell
6 i! q% h- f; m: a/ c. s  Y2 iTherapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 417
0 k4 |* m4 g" o& Z+ q3 k* d* u1 ^Hwal (Matthew) Suh8 E' I& S/ K; x2 U
Neural Stem Cells: From Cell Fate and Metabolic Monitoring1 @, h, D# ^& T. D$ x, b0 }
Toward Clinical Applications . . . . . . . . . . . . . . . . . . . . . . . . 435
, s  ^0 q1 i( M( j! {Jan Pruszak, Máté Döbrössy, Jochen Kieninger, Kuppusamy
9 V% u& {/ Y* h9 l: g; \& F# mAravindalochanan, Gerald A. Urban, and Guido Nikkhah( E+ K5 J3 I, u# @; i! s" q
Contents xxxiii# E9 p/ N( K6 }4 w
Adult Stem Cells in Drug Discovery . . . . . . . . . . . . . . . . . . . . 457/ c, n) k! m9 _( H" m, L+ h% ^
Stefan Golz, Andreas Geerts, and Andreas Wilmen
( L6 M$ f2 T4 uEmbryonic Stem Cells as a Tool for Drug Screening and Toxicity Testing 473
: }" J+ R9 S7 F& g( Z/ P' IBernd Denecke and Silke Schwengberg
9 T/ ^$ \4 w  I/ Y8 v6 TEmbryonic Stem Cells: A Biological Tool to Translate the0 R' ~* W3 O3 {( R
Mechanisms of Heart Development . . . . . . . . . . . . . . . . . . . . 501
7 }2 C+ T! F1 V4 I# ?4 [! H/ LOmonigho A. Aisagbonhi and Antonis K. Hatzopoulos9 {# K- t+ `! R/ w$ V1 |! w1 [
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 521

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