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本帖最后由 细胞海洋 于 2013-5-6 09:46 编辑 : K2 S/ `2 c: L1 j, L7 z& I
% U0 G# ~$ `4 s8 cThe Delivery of Regenerative Medicines and Their Impact on Healthcare
, _( c6 G+ c2 n" m3 N* p. \8 G+ }Edited by
( }$ u4 @- l' pDr. Catherine D. Prescott
6 U+ N+ N# o* B& rProfessor Dame Julia Polak8 y) {: d9 [2 Q" {
+ Q( l; f4 t; T( r6 q6 J w4 U1 X9 tContents
- {+ g/ ^8 Y% R# m7 |# w' uForeword...................................................................................................................vii! H& ~3 @& `' K6 R! d9 }
Preface.......................................................................................................................ix, U( i% V, {$ C; s
Acknowledgments......................................................................................................xi
9 p5 N3 P# ?5 xAbout the Editors.................................................................................................... xiii5 E5 Z$ b: X& E8 C5 O! u
Contributors..............................................................................................................xv" S0 ], Y: j4 ?5 v
Section 1 I ntroduction K" y4 M2 t4 V6 ?: V1 J; U$ D
Chapter 1 What Is Regenerative Medicine?...........................................................31 `! c' U9 @( O* p- R
Julia M. Polak/ g6 q/ V$ M/ I
Section 2 Finance& J% Z4 L9 e2 @, R
Chapter 2 A New Political–Financial Paradigm for Medical Research:
7 U* V& u0 T/ H/ tThe California Model?........................................................................ 119 r6 ^+ r/ ~ _5 U9 o' F3 S6 T
Robert N. Klein and Alan Trounson
% i# [! J, m- E# z3 } Y, C# ~Chapter 3 Investment Models: Public Funding in Australia................................ 35
" w) W8 d7 a% e+ m* T& ]. KGraham Macdonald
7 m% E5 A5 I( x: WChapter 4 Canada: Capitalizing on a 50-Year Legacy......................................... 43
0 E6 S6 o5 B6 J# Y# m( LAndrew Lyall
! C8 B( o& o* F7 @* q; ?Chapter 5 Investing in Regenerative Medicine: What Drives Private Investors?.... 59
8 L ~! m. {0 g; f% pCatherine D. Prescott2 A& f# {8 }9 I
Chapter 6 Public Investment Models: Coming out of the Closet and1 N+ W4 l7 U! \) c/ T
Going Public!...................................................................................... 67# z- u- J# p. e* f. }9 ?. r
Reni Benjamin$ n+ T: [% s& D9 T3 L( }
Section 3 Business Models
) M- r. R, n' e8 t+ s1 y9 `8 QChapter 7 Cell-Based Products: Allogeneic.........................................................85
( T6 O2 D# x1 Z: a. B. `Paul Kemp$ F& l; x4 B5 R) R+ ^
Chapter 8 Autologous Cell-Based Products: Fulfilling the Promise of) I( B& {9 h. J: w
Cell Therapy........................................................................................97
+ L5 M. y+ o$ kEduardo Bravo and Magdalena Blanco-Molina- l' {; l7 v& m1 L
Chapter 9 Business Models for Cord Blood....................................................... 1179 N+ u( |1 |9 Y/ ^! d# g
Suzanne M. Watt1 i1 P; ^! I; d$ ]% C
Chapter 10 Changing the Game of Drug Discovery............................................ 131# l; ^) F5 i0 T Q: ^. w- X% ^
John Walker
$ x' x6 P) H( E1 W Y2 N2 C1 J+ n& rChapter 11 Discovery of Small Molecule Regenerative Drugs........................... 141- d2 g1 j2 p0 X9 [
Yen Choo
3 h( S9 T7 [5 {6 y1 OChapter 12 Adoption of Therapeutic Stem Cell Technologies by Large
; q8 d( A, l9 z) Z: P6 R; m. nPharmaceutical Companies............................................................... 1533 i3 [; l0 \. o
Alain A. Vertès* s" l" A/ ]1 {3 y5 F* Y
Chapter 13 Role of Tool and Technology Companies in Successful
! y' ?' t, O8 UCommercialization of Regenerative Medicine.................................. 177
2 L+ U6 y* V, b0 C+ TJoydeep Goswami and Paul Pickering+ [# I+ M- e2 p8 m% s* ^. x1 H8 A
Chapter 14 Key Considerations in Manufacturing of Cellular Therapies........... 189, l+ X+ \) f9 _! P0 o, U) S* a1 ], U( Q
Robert A. Preti3 Q1 X4 J8 Q! g( x2 h! a
Chapter 15 State of the Global Regenerative Medicine Industry........................ 213
9 [- o. d" G4 }7 r* BR. Lee Buckler, Robert Margolin, and Sarah A. Haecker
. p+ n+ D) \. fSection 4 Intellectual Property
( x4 N# r' M5 [& B8 \0 aChapter 16 Regenerating Intellectual Property: Europe after WARF................. 239
+ I0 ^3 K; c- S& ^7 F* t# p$ VJulian Hitchcock and Devanand Crease
' o: K0 G& ^ M8 h- e `1 {Chapter 17 Protecting Regenerative Medicine Intellectual Property in the" B" j% c" a1 Y
United States: Problems and Strategies............................................. 2573 Z- o3 k, Y# G! B. p
David Resnick, Ronald I. Eisenstein, and Joseph M. McWilliams
3 [3 \' o! F* cChapter 18 Impacts of Indian Policies and Laws on Regenerative
. [8 ?( ^2 i9 K J' z5 O* d0 RMedicine Patent Applications........................................................... 281
6 h# @8 @$ N" V6 {! t5 S% l, x1 uPrabuddha Ganguli
9 J! \" M2 M2 A3 I/ z GSection 5 Regulatory Landscape9 c+ L* r5 l# A4 J, y( T
Chapter 19 A CATalyst for Change: Regulating Regenerative Medicines in* \$ z* |+ l9 E
Europe...............................................................................................295
* x5 g4 ~( l8 MChristopher A. Bravery
6 P+ l0 i: g) H. l* ?/ q, _Chapter 20 United States Regulatory Reimbursement, Political
$ l' u; d" p/ [+ OEnvironment, and Strategies for Reform........................................... 323
' Y) P% V( t2 k8 t! eMichael J. Werner
. h2 t$ c `7 W: y( cSection 6 Reimbursement
: Y( b: A/ A1 V+ IChapter 21 The Fourth Hurdle: Reimbursement Strategies for8 {1 M" J3 M( b' M3 T e7 \9 G
Regenerative Medicine in Europe..................................................... 337
5 [( D% F& j( xFrançois M. Meurgey and Micheline Wille
9 B6 v8 B8 k: p+ v% z+ zChapter 22 Cellular Therapies and Regenerative Medicine: Preparing for0 v. v& b, T* C& s% c. `! J
Reimbursement in the United States................................................. 3510 v7 l; j2 I9 Q$ S) n Z7 |
Eric Faulkner
8 [! T& @% J& YChapter 23 Adoption and Evaluation of Regenerative Medicine and the
6 q0 t/ i. b( wNational Health Service....................................................................3695 n7 V: t& a/ M, n8 d9 y
Margaret Parton+ k( I: D( k" ^' X% @
Section 7 I nsurance and Risk Management9 V+ ?, b+ f4 @
Chapter 24 Role of Insurance: If You Build It, Will They Insure It?.................. 379/ n: z$ D" f* y8 Q; T2 U
Matthew Clark
1 ^& F. }$ C4 {# B0 S, SIndex....................................................................................................................... 391+ {9 h8 O. Q, z2 H# w
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