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1 D! k* U* r6 w7 k) ]: f; X0 n1 i8 y2 J% {23 May, 2013 Volume 153, Issue 51 q; m0 a& N# b9 B: k4 e* T: Q+ }& W
On the cover: For years, lineage specifiers have generally been considered as rivals to factors that induce cellular reprogramming into pluripotency, including Oct4. Shu et al. (pp. 963–975) find that a combination of lineage-specifying proteins, however, can replace Oct4 and Sox2 to establish pluripotency. The authors propose a “seesaw model,” in which lineage specifiers facilitate reprogramming when they are balanced with other mutually exclusive lineage specifiers. The cover features a scene in which two children playing seesaw depict the seesaw model. The two children represent two antagonistic forces (mutually exclusive lineage specifiers ME and ECT). Artwork by Yuzhou Tian and Jian Shu.
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发表于 2013-5-24 00:22
