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Brain construction goes straight [复制链接]

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楼主
发表于 2009-3-6 08:10 |只看该作者 |倒序浏览 |打印
Brains of mice lacking the cell adhesion molecule L1 are a mess. Failures in neural migration, pathfinding, morphogenesis, and fasciculation result in shortages of cells in various regions and aberrant architecture. But now Itoh et al. (page 145) report that homophilic binding of L1 is not necessary for axonal guidance and neuronal migration in the central nervous system (CNS).
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% `  W/ q; |+ E0 IL1 was one of the first neural cell adhesion molecules to be discovered, and its binding partners have been proliferating ever since. Many of those binding partners contact several of L1's many domains, making individual contributions difficult to tease apart. Itoh et al., however, succeed in ablating only a subset of L1's binding interactions via a deletion of L1's sixth Ig domain.
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The resulting protein does not bind either to itself or to 5?1 integrin. And yet mice expressing only this variant have brains and spinal cords that look normal. Thus, it seems that L1 homophilic binding, earlier found to mediate neurite outgrowth in vitro, is not needed for this function in the CNS.
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When the L1 variant is backcrossed into another mouse strain, the progeny get hydrocephalus. This swelling of the brain results when cerebrospinal fluid is not correctly cleared from the brain ventricles. The link between L1 mutation and hydrocephalus has been noted before, in humans, but its mechanistic basis remains unclear.(Pathfinding is fine without L1–L1 bindin)

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沙发
发表于 2015-6-1 08:27 |只看该作者
是楼主原创吗  

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藤椅
发表于 2015-7-2 13:53 |只看该作者
你加油吧  

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板凳
发表于 2015-7-3 16:36 |只看该作者
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呵呵,明白了  

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报纸
发表于 2015-7-9 12:27 |只看该作者
来几句吧  

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地板
发表于 2015-8-22 09:38 |只看该作者
我帮你 喝喝  

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发表于 2015-8-31 17:53 |只看该作者
不错不错.,..我喜欢  

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发表于 2015-9-7 14:27 |只看该作者
牛牛牛牛  

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发表于 2015-9-9 06:59 |只看该作者
ips是诱导多能干细胞induced pluripotent stem cells iPS

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发表于 2015-10-8 15:43 |只看该作者
今天没事来逛逛  
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