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On the cover: Developmental mechanisms generate
; @4 i7 T9 J0 W5 U1 u/ uinterspecies hybrids that cannot propagate, as alluded to by the artist's ; R6 N$ d. E# ^1 K' e
depiction of the mythical Minotaur's labyrinth on the cover. However, even
6 U4 `+ \$ f- O3 _# D3 b* P$ F" ?socially na?ve animals rarely mate with members of other species. The mechanisms ; |' U$ x% o/ w; z. A
that control such behavioral reproductive isolation, an important tenet of ) L t! l2 T# H
evolution, are not well understood. As depicted on the cover, male flies tap
+ y) s( i9 S* X9 r- S) Uother flies with their foreleg prior to attempting to mate. Fan et al. (pp.
3 J u* i' A: V! C89–102) show that foreleg removal permits males to mate with flies of other
p( f' j. W; ] B Zspecies. Activation of foreleg neurons expressing the chemoreceptor Gr32a is
9 I) a0 {$ C& `2 I, I0 Fnecessary and sufficient to inhibit interspecies courtship by D.
! h; h' w! \8 p& G* ?& n8 p) p emelanogastermales. Gr32a is required to detect aversive hydrocarbons found * M+ g1 K: p) f w; P& N3 u
on the cuticle of other drosophilid species, and one such hydrocarbon,
( d! ^" m( @$ S7 `2 b2 \, @, Hz-11-pentacosene, is visible on the female fly on the cover. Strikingly, female
$ W" V2 Q, t% ?& y H. cflies utilize a Gr32a-independent mechanism to reject males of other species, 6 b# u: M; ?! c4 {4 E" g) c
with the cover depicting the female fly rejecting the male who is tapping her. 0 c; u( f- B- b( `
Cover art by Julie Newdoll. + o; l8 m, f4 B! |% G. V8 S2 @$ ]* S
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