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9 B& }+ C+ b' S* z2 [3 e; eVolume 154, Issue 2$ y9 g+ [1 B6 A8 U; B' U
On the cover: In this issue of Cell, Terasaki et al. (pp. 285–296)
/ i- m: v, ~# f0 W. ~9 Kexplain how parallel sheets of endoplasmic reticulum are connected. The
' c, z% m" N- T2 i3 j8 kexistence of these sheet stacks and their function in synthesis of membrane and
; `4 X o! ?3 Qsecreted proteins has been known for more than 60 years. Three-dimensional 2 A2 Y( x+ L/ Y
reconstructions from serial section electron micrographs from mouse salivary / z0 N) z/ J" p+ E
gland show that the sheets are connected by twisted membrane surfaces with
; s6 r" p5 h2 z5 khelical edges. The overall structure resembles a parking garage, in which the 7 `4 c5 g6 z& n( a% L# R$ ^1 O$ q9 p
different levels are connected by helicoidal ramps. Theoretical calculations
% x8 m1 I) t% S, v' Q& Kshow that this structure minimizes the elastic energy of sheet edges and
/ Y( a% h+ W* y0 A# Qsurfaces and allows dense packing of this organelle in the restricted space of a
/ y2 J* Z$ h5 Ycell.
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发表于 2013-7-19 19:50
发表于 2013-7-19 20:06
