《细胞》[Cell]13年7月18日出版pdf全文

nero1981

, A8 F  _, @$ L, q( Z; a' n( Q3 ]Volume 154, Issue 2
( A; Q1 h$ L9 T* c, sOn the cover: In this issue of Cell, Terasaki et al. (pp. 285–296)
" }2 s. v4 u% M1 c/ \) wexplain how parallel sheets of endoplasmic reticulum are connected. The
- B( f- m7 Z7 Bexistence of these sheet stacks and their function in synthesis of membrane and 1 y  r3 g) h' z7 D) D; Z
secreted proteins has been known for more than 60 years. Three-dimensional
: M! c) w% ~# jreconstructions from serial section electron micrographs from mouse salivary 3 a0 q) P- e) }. ?: v7 u# n. n
gland show that the sheets are connected by twisted membrane surfaces with 9 u! `/ J- P; V; c7 r4 x% K7 ?
helical edges. The overall structure resembles a parking garage, in which the 0 w7 H8 w9 A, H/ H* d) o
different levels are connected by helicoidal ramps. Theoretical calculations
3 |+ L9 e- ~8 Ishow that this structure minimizes the elastic energy of sheet edges and
9 ~: g4 q  Y$ {9 |3 T0 Lsurfaces and allows dense packing of this organelle in the restricted space of a
% K; m& b% L8 c. l& |cell.7 A. v' y9 X- m- w. m

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exin11

exin11

exin11

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你发错了，这是nature的# v! G- {* v+ e2 N1 U3 Z$ W

tpwang

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thanks

chichao0000

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chichao0000

请速更改，这是nature$ H1 ?& E  i4 M

osterix

Protein.Arrays,.Biochips,.and.Proteomics

nydfy

THX!!!

zhaoyoungyoung

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